分枝杆菌感染中巨噬细胞的形态、功能及表型：来自结核病和其他疾病的经验教训
Macrophage form, function, and phenotype in mycobacterial infection: lessons from tuberculosis and other diseases.
作者信息
McClean Colleen M, Tobin David M
机构信息
Department of Molecular Genetics and Microbiology, Duke University School of Medicine, DUMC 3020, Durham, NC 27710, USA Department of Immunology, Duke University School of Medicine, Durham, NC 27710, USA Medical Scientist Training Program, Duke University School of Medicine, Durham, NC 27710, USA.
Department of Molecular Genetics and Microbiology, Duke University School of Medicine, DUMC 3020, Durham, NC 27710, USA Department of Immunology, Duke University School of Medicine, Durham, NC 27710, USA
出版信息
Pathog Dis. 2016 Oct;74(7). doi: 10.1093/femspd/ftw068. Epub 2016 Jul 10.
Macrophages play a central role in mycobacterial pathogenesis. Recent work has highlighted the importance of diverse macrophage types and phenotypes that depend on local environment and developmental origins. In this review, we highlight how distinct macrophage phenotypes may influence disease progression in tuberculosis. In addition, we draw on work investigating specialized macrophage populations important in cancer biology and atherosclerosis in order to suggest new areas of investigation relevant to mycobacterial pathogenesis. Understanding the mechanisms controlling the repertoire of macrophage phenotypes and behaviors during infection may provide opportunities for novel control of disease through modulation of macrophage form and function.
巨噬细胞在分枝杆菌致病过程中发挥核心作用。近期研究突出了依赖局部环境和发育起源的多种巨噬细胞类型及表型的重要性。在本综述中，我们强调了不同的巨噬细胞表型如何影响结核病的疾病进展。此外，我们借鉴了对癌症生物学和动脉粥样硬化中重要的特殊巨噬细胞群体的研究工作，以提出与分枝杆菌致病机制相关的新研究领域。了解感染期间控制巨噬细胞表型和行为库的机制，可能为通过调节巨噬细胞形态和功能实现疾病的新型控制提供机会。
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