Guo Lihua, Yu Min, Zhong Jieming, Wu Haibin, Pan Jin, Gong Weiwei, Wang Meng, Fei Fangrong, Hu Ruying
Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou 310051, China.
Int J Endocrinol. 2016;2016:6380620. doi: 10.1155/2016/6380620. Epub 2016 Jun 14.
Objective. This study aimed to explore the incidence of stroke and stroke subtypes among patients with type 2 diabetes mellitus (T2DM) based on the long-term surveillance data in Zhejiang, China, during 2007 to 2013. Materials and Methods. During January 1, 2007, and December 31, 2013, a total of 327,268 T2DM and 307,984 stroke patients were registered on Diabetes and Stroke Surveillance System, respectively. Stroke subtypes were classified according to standard definitions of subarachnoid hemorrhage, intracerebral hemorrhage, and ischemic stroke. The incidence of stroke and stroke subtypes was calculated by standardized incidence ratio (SIRs) with 95% confidence intervals (CIs) compared with general population. Results. The incidence of stroke and stroke subtypes among patients with T2DM was significantly higher than in general population. Stroke risk was found significantly increased with an SIR of 3.87 (95% CI 3.76-3.99) and 3.38 (95% CI 3.27-3.48) in females and males, respectively. The excess risk of stroke was mainly attributable to the significantly higher risk of cerebral infarctions with the risk for T2DM being four times that for general population. Conclusions. The relationship between stroke and T2DM was strong, especially in female. The incidence of stroke and stroke subtypes among patients with T2DM was up to 3-fold higher than in general population in Zhejiang province, especially the subtype of cerebral infarctions.
目的。本研究旨在基于2007年至2013年中国浙江省的长期监测数据，探讨2型糖尿病（T2DM）患者中中风及中风亚型的发病率。材料与方法。在2007年1月1日至2013年12月31日期间，糖尿病和中风监测系统分别登记了327,268例T2DM患者和307,984例中风患者。中风亚型根据蛛网膜下腔出血、脑出血和缺血性中风的标准定义进行分类。通过标准化发病率比（SIRs）及95%置信区间（CIs）计算中风及中风亚型的发病率，并与普通人群进行比较。结果。T2DM患者中中风及中风亚型的发病率显著高于普通人群。女性和男性的中风风险均显著增加，SIR分别为3.87（95%CI 3.76 - 3.99）和3.38（95%CI 3.27 - 3.48）。中风的额外风险主要归因于脑梗死风险显著更高，T2DM患者的风险是普通人群的四倍。结论。中风与T2DM之间的关系密切，尤其是在女性中。浙江省T2DM患者中中风及中风亚型的发病率比普通人群高出多达3倍，尤其是脑梗死亚型。
