Shi Shaojun, Xue Feng
Department of Liver Surgery and Liver Transplantation Center, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China.
Oxid Med Cell Longev. 2016;2016:8678510. doi: 10.1155/2016/8678510. Epub 2016 Jun 15.
Oxidative stress is one of the key mechanisms affecting the outcome throughout the course of organ transplantation. It is widely believed that the redox balance is dysregulated during ischemia and reperfusion (I/R) and causes subsequent oxidative injury, resulting from the formation of reactive oxygen species (ROS). Moreover, in order to alleviate organ shortage, increasing number of grafts is retrieved from fatty, older, and even non-heart-beating donors that are particularly vulnerable to the accumulation of ROS. To improve the viability of grafts and reduce the risk of posttransplant dysfunction, a large number of studies have been done focusing on the antioxidant treatments for the purpose of maintaining the redox balance and thereby protecting the grafts. This review provides an overview of these emerging antioxidant treatments, targeting donor, graft preservation, and recipient as well.
氧化应激是影响器官移植全过程结果的关键机制之一。人们普遍认为，缺血再灌注（I/R）期间氧化还原平衡失调，会因活性氧（ROS）的形成而导致随后的氧化损伤。此外，为了缓解器官短缺问题，越来越多的移植物取自肥胖、老龄甚至非心脏跳动供体，这些供体特别容易发生ROS积累。为了提高移植物的活力并降低移植后功能障碍的风险，已经开展了大量研究，重点是抗氧化治疗，目的是维持氧化还原平衡，从而保护移植物。本综述概述了这些新兴的抗氧化治疗方法，其靶向对象还包括供体、移植物保存和受体。
