Ferencváros Health Centre, Gastroenterology, Budapest, Hungary.
Synlab Ltd, Budapest, Hungary.
United European Gastroenterol J. 2016 Jun;4(3):388-94. doi: 10.1177/2050640615610265. Epub 2015 Oct 13.
Some gastric cancers are Epstein-Barr virus associated.
To assess the prevalence of Helicobacter pylori and viral co-infection in benign upper digestive diseases.
One hundred and four outpatients were included in a prospective endoscopic-serologic study. Epstein-Barr virus immunoglobulin G (IgG), immunoglobulin M and viral capsid antigen titres were assayed with an ELISA test. Helicobacter pylori was determined by the modified Giemsa stain and by IgG-chemiluminescence.
The overall prevalence of Helicobacter pylori was 56.7%. Duodenal ulcer patients were infected in 72.5 % of the cases, with the prevalence being 33.3% in functional dyspepsia (p = 0.0008) and 25.8% in reflux patients (p = 0.0001). Epstein-Barr virus IgG was detected in 70.1% of the whole group, 75% of duodenal ulcer patients, 51.2% of functional dyspepsia patients (p = 0.04) and 51.6% of the reflux disease cases (p = 0.04). Co-infection with both agents was detected in 60% of duodenal ulcer patients, 18.1% of functional dyspepsia (p = 0.00014) and 12.9% of reflux disease patients (p = 0.00012). Anti-viral IgG titre displayed a 31.7 ± 3.0 cut-off index in duodenal ulcer, 20.5 ± 3.5 in functional dyspepsia (p = 0.01) and 21.4 ± 3.6 in reflux cases (p = 0.03).
Both Helicobacter pylori and Epstein-Barr virus, and co-infection with these agents, were significantly more prevalent in duodenal ulcer patients than in dyspeptic/reflux patients.
有些胃癌与 Epstein-Barr 病毒相关。
评估幽门螺杆菌和病毒合并感染在上消化道良性疾病中的流行情况。
104 例门诊患者纳入一项前瞻性内镜-血清学研究。采用 ELISA 试验检测 Epstein-Barr 病毒免疫球蛋白 G（IgG）、免疫球蛋白 M 和病毒衣壳抗原滴度。通过改良吉姆萨染色和 IgG-化学发光法检测幽门螺杆菌。
幽门螺杆菌总感染率为 56.7%。十二指肠溃疡患者感染率为 72.5%，功能性消化不良患者为 33.3%（p=0.0008），反流病患者为 25.8%（p=0.0001）。整个研究组中，70.1%的患者检测出 Epstein-Barr 病毒 IgG，十二指肠溃疡患者中为 75%，功能性消化不良患者中为 51.2%（p=0.04），反流病患者中为 51.6%（p=0.04）。两种病原体合并感染在十二指肠溃疡患者中检出率为 60%，功能性消化不良患者中为 18.1%（p=0.00014），反流病患者中为 12.9%（p=0.00012）。抗病毒 IgG 滴度在十二指肠溃疡患者中截断值为 31.7±3.0，在功能性消化不良患者中为 20.5±3.5（p=0.01），在反流病患者中为 21.4±3.6（p=0.03）。
幽门螺杆菌和 Epstein-Barr 病毒以及两者的合并感染在十二指肠溃疡患者中比在消化不良/反流病患者中更为常见。
