Saleem Mohd Nauman, Idris Mohammad
Post Graduate Department of Ilm-us-Saidla, Ayurvedic & Unani Tibbia College, Karol Bagh, New Delhi 110005, India.
Departments of Ilm-us-Saidla & Advia, Ayurvedic & Unani Tibbia College, Karol Bagh, New Delhi 110005, India.
Scientifica (Cairo). 2016;2016:7602347. doi: 10.1155/2016/7602347. Epub 2016 Jun 15.
The Transdermal Drug Delivery System (TDDS) is one of the novel routes for systemic delivery of drugs through intact skin. A transdermal patch (TP) is a medicated patch that is placed on skin for delivery of medication through skin into the blood stream. The aim of present study was to formulate and evaluate a Unani transdermal patch that could be used for antiemetic therapy. The incorporation of Unani ingredients, namely, Khardal (Brassica nigra), Zanjabeel (Zingiber officinale), Podina (Mentha arvensis), and Sirka (Vinegar) were envisaged. The TP was prepared by solvent evaporation technique and was evaluated for organoleptic characteristics and other physicochemical properties, such as thickness, weight uniformity, folding endurance, moisture content, drug content, and tolerability and acceptability of patch. The in vitro permeation study of the patch was carried out through Franz diffusion cell using egg shell membrane as barrier membrane. Phosphate buffer pH 7.4 was used as dissolution medium and the temperature was maintained at 37 ± 1°C. The in vitro permeation study of the prepared TP indicated a time dependent increase in drug release throughout the study. The percentage of cumulative drug release was found to be 77.38% in 24 hours. The study shows a new approach to work in Unani pharmaceutics.
经皮给药系统（TDDS）是通过完整皮肤进行药物全身给药的新型途径之一。透皮贴剂（TP）是一种药用贴剂，贴于皮肤上用于将药物透过皮肤输送到血流中。本研究的目的是制备并评估一种可用于止吐治疗的尤那尼（Unani）透皮贴剂。设想加入尤那尼成分，即黑芥子（Brassica nigra）、姜（Zingiber officinale）、薄荷（Mentha arvensis）和醋（Vinegar）。透皮贴剂采用溶剂蒸发技术制备，并对其感官特性和其他物理化学性质进行评估，如厚度、重量均匀性、耐折性、水分含量、药物含量以及贴剂的耐受性和可接受性。通过Franz扩散池，以蛋壳膜作为屏障膜，对该贴剂进行体外渗透研究。使用pH 7.4的磷酸盐缓冲液作为溶出介质，温度保持在37±1°C。所制备透皮贴剂的体外渗透研究表明，在整个研究过程中药物释放呈时间依赖性增加。24小时内累积药物释放百分比为77.38%。该研究展示了尤那尼药剂学的一种新的研究方法。
