Jaber Saif Aldeen
Faculty of Pharmacy, Middle East University, Amman, Jordan.
Applied Science Research Center, Applied Science Private University, Amman, Jordan.
J Adv Pharm Technol Res. 2023 Jul-Sep;14(3):202-207. doi: 10.4103/japtr.japtr_130_23. Epub 2023 Jul 28.
Biofilm-forming bacteria have sent alarms to the world about the emerging of bacterial resistance. Gentamycin is an aminoglycoside broad-spectrum antibiotic used against microbial infections. The transdermal drug delivery method is a major system used to reduce drug toxicity and avoid first-pass metabolism. Gentamycin was formulated in a transdermal polymeric formula using hydroxypropyl methylcellulose (HPMC), polyvinylpyrrolidone (PVP), and Chitosan in the presence of palmitic acid as a permeation enhancer. In this research, gentamycin extended drug release behavior was successfully done in different polymeric formulas containing (HPMC/PVP) and (HPMC/Chitosan), with a maximum drug release of <70%. In addition, drug diffusion was found to be dependent on the rate of drug release. The controlled release formulas selected for antimicrobial assay show that HPMC/Chitosan formulas have successfully inhibited microbial and biofilm growth by 90%. In conclusion, gentamycin can be formulated in a transdermal polymeric film to target skin infection, reduce drug side effects and avoid drug first-pass metabolism.
形成生物膜的细菌已就细菌耐药性的出现向全世界发出警报。庆大霉素是一种用于对抗微生物感染的氨基糖苷类广谱抗生素。透皮给药方法是一种主要用于降低药物毒性和避免首过代谢的系统。在棕榈酸作为渗透促进剂存在的情况下，使用羟丙基甲基纤维素（HPMC）、聚乙烯吡咯烷酮（PVP）和壳聚糖将庆大霉素制成透皮聚合物配方。在本研究中，庆大霉素在含有（HPMC/PVP）和（HPMC/壳聚糖）的不同聚合物配方中成功实现了延长药物释放行为，最大药物释放率<70%。此外，发现药物扩散取决于药物释放速率。选择用于抗菌测定的控释配方表明，HPMC/壳聚糖配方已成功抑制微生物和生物膜生长达90%。总之，庆大霉素可制成透皮聚合物薄膜，以靶向皮肤感染、减少药物副作用并避免药物首过代谢。
