Interaction of reinforcement history with methadone on responding maintained under a fixed-interval schedule.

Twelve pigeons were initially trained under either a fixed-ratio (FR) 50 or differential-reinforcement-of-low-rate (DRL) 10-sec schedule of food presentation. After 50 sessions of exposure to the foregoing schedules all pigeons key pecked under a fixed-interval (FI) 90-sec schedule. Key-peck rates differed as a function of schedule history, with FR-history subjects responding at significantly higher rates under the FI schedule than DRL-history subjects. To better compare methadone's rate-altering effects on baseline response rates, 8 naive pigeons were trained from the outset to key peck under an FI 90-sec schedule and were subsequently divided into 2 groups based on overall response rates (groups FI-H and FI-L). After at least 40 sessions under the FI schedule methadone dose-response curves were determined at doses of 0.6, 1.2 and 2.4 mg/kg. Low and intermediate methadone doses did not effect key-peck rates by pigeons with an FR history compared to significant rate decreases by pigeons having comparable rates but without a history of responding under an FR schedule (group FI-H). No differential effects following methadone were observed in low-rate subjects (DRL history and FI-L). When methadone (9.0 and 12.0 mg/kg/day) was administered chronically, response rates of all subjects were initially suppressed, with FI control subjects showing more complete recovery of drug-free baselines than either FR- or DRL-history groups. Naloxone (1.0 mg/kg) reversed methadone's rate-decreasing effects, although these actions were significantly less in subjects with prior experience under DRL schedules. Following completion of the chronic phase, and when subjects had been drug free for at least 14 sessions, the methadone dose-response curve was redetermined. The differential effects of methadone associated with reinforcement history were no longer evident, suggesting that a drug history can interact with a schedule history. These experiments add to the growing body of evidence indicating that prior experience can influence the behavioral actions of drugs independent of control rate of responding. Moreover, the data reveal that the influence of reinforcement schedule history depends on whether drugs are administered acutely or chronically.