McFarland D J
Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany 12201.
Pharmacol Biochem Behav. 1989 Mar;32(3):723-6. doi: 10.1016/0091-3057(89)90024-5.
The sequencing of arm entries in a symmetrical Y-maze was examined in mice treated with either scopolamine, d-amphetamine or apomorphine. These treatments could potentially alter both alternation tendencies and rotational tendencies. Therefore, a measure of spontaneous alternation was evaluated which was computed by taking an average of the right going percent alternation and the left going percent alternation. The number of arm entries was increased by amphetamine, unchanged following scopolamine and reduced by apomorphine. All three drugs reduced spontaneous alternation tendencies and increased the magnitude of a bias to turn consistently in the same direction (rotational tendency). All three drugs thus altered the sequencing of arm entries from patterns consistent with spatial alteration to patterns consistent with egocentrically defined responses. These results indicate that the measure of spontaneous alternation which was an average of the right going percent alternation and the left going percent alternation is a better index of alternation tendencies. Thus, when an animal is not able to navigate on the basis of an extrapersonal (allocentric) system as a result of drug treatment, it will revert to an egocentric system.
在接受东莨菪碱、右旋苯丙胺或阿扑吗啡治疗的小鼠中，研究了对称Y型迷宫中进入臂的顺序。这些治疗可能会改变交替倾向和旋转倾向。因此，评估了一种自发交替的测量方法，该方法通过计算向右进入百分比交替和向左进入百分比交替的平均值来计算。右旋苯丙胺增加了进入臂的次数，东莨菪碱处理后次数不变，阿扑吗啡则减少了进入臂的次数。所有三种药物都降低了自发交替倾向，并增加了始终朝同一方向转动的偏差幅度（旋转倾向）。因此，所有三种药物都将进入臂的顺序从与空间交替一致的模式改变为与以自我为中心定义的反应一致的模式。这些结果表明，作为向右进入百分比交替和向左进入百分比交替平均值的自发交替测量方法是交替倾向的更好指标。因此，当动物由于药物治疗而无法基于超个人（以自我为中心）系统导航时，它将恢复到以自我为中心的系统。
