Tanaka S, Yoon Y H, Fukui H, Tabata M, Akira T, Okano K, Iwai M, Iga Y, Yokoyama K
Planta Med. 1989 Jun;55(3):245-8. doi: 10.1055/s-2006-961994.
Two active compounds that prevent serotonin-induced ulcerogenesis in rats were isolated from Chinese cinnamon (the stem bark of Cinnamomum cassia) and identified as 3-(2-hydroxyphenyl)-propanoic acid and its O-glucoside. The former compound, administered orally or parenterally to rats at a remarkably low dose (40 micrograms/kg body weight), also inhibited gastric ulcers induced by the other ulcerogens such as phenylbutazone, ethanol, and water immersion stress, although it failed to prevent indomethacin-induced ulcers. Pharmacological studies have shown that 3-(2-hydroxyphenyl)-propanoic acid hardly inhibited the secretion of gastric acid, but promoted the gastric blood flow. These results suggest that the antiulcerogenic effect of this compound is probably attributable to the potentiation of defensive factors through the improvement of the circulatory disorder and gastric cytoprotection.
从中国肉桂（肉桂树的茎皮）中分离出两种可防止血清素诱导大鼠发生溃疡的活性化合物，它们被鉴定为3-(2-羟基苯基)丙酸及其O-葡萄糖苷。前一种化合物以极低剂量（40微克/千克体重）口服或注射给大鼠时，也能抑制由其他致溃疡剂如保泰松、乙醇和水浸应激诱导的胃溃疡，尽管它不能预防吲哚美辛诱导的溃疡。药理学研究表明，3-(2-羟基苯基)丙酸几乎不抑制胃酸分泌，但能促进胃血流量。这些结果表明，该化合物的抗溃疡作用可能归因于通过改善循环障碍和胃细胞保护作用增强了防御因子。
