Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan.
BMC Complement Altern Med. 2010 Aug 18;10:45. doi: 10.1186/1472-6882-10-45.
Korean red ginseng (KRG) is a ginseng that has been cultivated and aged for 4-6 years or more, and goes through an extensive cleaning, steaming and drying process. KRG contains more than 30 kinds of saponin components and has been reported as having various biological properties, such as anti-fatigue action, immune restoration, and neurovegetative effect. The purpose of this study was to assess the effects of a KRG-containing drug (KRGCD) on gastric ulcer models in mice.
Stomach ulcers were induced by oral ingestion of hydrochloride (HCl)/ethanol or indomethacin. Treatment with KRGCD (30, 100, and 300 mg/kg, p.o.) occurred 1 hr before the ulcer induction. Effect of KRGCD on anti-oxidant activity and gastric mucosal blood flow with a laser Doppler flowmeter in mice stomach tissue was evaluated.
KRGCD (100 and 300 mg/kg, p.o.) significantly decreased ethanol- and indomethacin-induced gastric ulcer compared with the vehicle-treated (control) group. KRGCD (100 and 300 mg/kg) also decreased the level of thiobarbituric acid reactive substance (TBARS) and increased gastric mucosal blood flow compared with the control group.
These results suggest that the gastroprotective effects of KRGCD on mice ulcer models can be attributed to its ameliorating effect on oxidative damage and improving effect of gastric mucosal blood flow.
红参是一种经过 4-6 年或更长时间的栽培和陈化，并经过广泛的清洗、蒸煮和干燥过程的人参。红参含有 30 多种皂苷成分，据报道具有多种生物特性，如抗疲劳作用、免疫恢复和神经植物作用。本研究旨在评估含红参药物（KRGCD）对小鼠胃溃疡模型的影响。
通过口服盐酸（HCl）/乙醇或吲哚美辛诱导胃溃疡。在溃疡诱导前 1 小时给予 KRGCD（30、100 和 300mg/kg，po）治疗。用激光多普勒血流仪评估 KRGCD 对小鼠胃组织抗氧化活性和胃黏膜血流的影响。
与 vehicle-treated（对照）组相比，KRGCD（100 和 300mg/kg，po）显著降低了乙醇和吲哚美辛诱导的胃溃疡。与对照组相比，KRGCD（100 和 300mg/kg）还降低了丙二醛（TBARS）的水平，并增加了胃黏膜血流。
这些结果表明，KRGCD 对小鼠溃疡模型的胃保护作用可能归因于其对氧化损伤的改善作用和对胃黏膜血流的改善作用。
