Erickson Steven R, Spoutz Patrick, Dorsch Michael, Bleske Barry
University of Michigan College of Pharmacy, Department of Pharmacy Practice, United States.
Department of Veterans Affairs, VISN Region 15, Kansas City, MO, United States.
Int J Cardiol. 2016 Oct 15;221:371-5. doi: 10.1016/j.ijcard.2016.07.044. Epub 2016 Jul 5.
People with intellectual/developmental disabilities (IDDs) face the development of cardiovascular disease (CVD) similar to the general population. The purpose of this study was to describe and compare the presence of CVD risk factors, the atherosclerotic cardiovascular (ASCVD) risk score, and medication prescribing patterns for medications to treat related risk factors for patients with IDD and those without.
This was a retrospective study of patients age 18years and older of a health system's primary care medicine practices. The IDD group had documentation of a diagnosis related to IDD. The comparison group was a random sample of patients from the same practices who had no indication of IDD. Patient characteristics included demographics, smoking status, cholesterol, and blood pressure. The presence of a diagnosis of hypertension, hyperlipidemia, diabetes, coronary artery disease, history of stroke or myocardial infarction, and related medication therapy were documented. The dependent variable was the estimated 10-year primary risk of ASCVD.
The IDD group included 78 patients while the GenMed group included 187. There were no significant differences in the prevalence of risk-related diagnoses or in blood pressure and cholesterol between the two groups. The estimated 10-year ASCVD risk was significantly higher in the GenMed group compared to the IDD group (p=0.02). Prescribing was similar between the groups. The regression analysis found that group assignment was not significantly associated with ASCVD risk, while age, gender, and race were.
CV risk and related treatment among patients with IDD was similar to that of the general population.
智力/发育障碍（IDD）患者面临与普通人群相似的心血管疾病（CVD）发病风险。本研究旨在描述和比较IDD患者与非IDD患者的CVD危险因素、动脉粥样硬化性心血管（ASCVD）风险评分以及治疗相关危险因素的药物处方模式。
这是一项对某医疗系统初级保健医疗实践中18岁及以上患者的回顾性研究。IDD组有与IDD相关的诊断记录。对照组是来自相同医疗实践且无IDD迹象的患者随机样本。患者特征包括人口统计学信息、吸烟状况、胆固醇和血压。记录高血压、高脂血症、糖尿病、冠状动脉疾病、中风或心肌梗死病史以及相关药物治疗的诊断情况。因变量是估计的10年ASCVD主要风险。
IDD组包括78名患者，而普通内科（GenMed）组包括187名。两组在风险相关诊断的患病率、血压和胆固醇方面无显著差异。与IDD组相比，GenMed组估计的10年ASCVD风险显著更高（p = 0.02）。两组之间的处方情况相似。回归分析发现，分组与ASCVD风险无显著关联，而年龄、性别和种族与ASCVD风险有关。
IDD患者的心血管风险及相关治疗与普通人群相似。
