Glacet-Bernard Agnes, Sellam Alexandre, Coscas Florence, Coscas Gabriel, Souied Eric H
Department of Ophthalmology, Centre Hospitalier Intercommunal de Créteil, Université Paris Est-Créteil, Créteil - France.
Centre Ophtalmologique de l'Odeon, Paris - France.
Eur J Ophthalmol. 2016 Aug 4;26(5):460-8. doi: 10.5301/ejo.5000829. Epub 2016 Jul 12.
To quantitatively and qualitatively analyze patients with macular edema secondary to retinal vein occlusion (RVO) and treated with the intravitreal dexamethasone implant using optical coherence tomography angiography (OCTA).
The files of patients treated with intravitreal injection of dexamethasone implant for macular edema secondary to RVO were retrospectively analyzed. Before and after injection, the following data were recorded: best-corrected visual acuity (BCVA), central macular thickness (CMT) measured using spectral-domain optical coherence tomography, fluorescein angiography, and OCTA (Optovue, Inc., Fremont, CA, USA). Results of automatic measurement of vascular density of the superficial capillary plexus (SCP) and deep capillary plexus were obtained before and after treatment and compared to those of healthy subjects matched for age and sex.
Seven eyes of 7 patients (mean age, 76 years; 57% male) were analyzed, including 3 cases of central RVO and 4 cases of branch RVO. All patients received 1 intravitreal injection of dexamethasone implant. After a mean follow-up of 2 months, CMT significantly decreased from 657 µm to 324 µm on average and BCVA increased from 20/100 to 20/50 (p = 0.017 and p<0.001, respectively). At the SCP, the mean whole en face vascular density slightly decreased during follow-up from 43.21% to 42.76% (not statistically significant). Vascular densities were largely inferior to those observed in control subjects (p≤0.01 in all quadrants).
This study confirms the potential contribution of OCTA as a novel noninvasive imaging technology that enables a quantitative and qualitative evaluation of the follow-up of macular edema in RVO. Optical coherence tomography angiography may complement advantageously multimodal imaging to monitor patients with RVO.
使用光学相干断层扫描血管造影（OCTA）对视网膜静脉阻塞（RVO）继发黄斑水肿并接受玻璃体内地塞米松植入治疗的患者进行定量和定性分析。
回顾性分析接受玻璃体内注射地塞米松植入物治疗RVO继发黄斑水肿患者的病历。在注射前后，记录以下数据：最佳矫正视力（BCVA）、使用光谱域光学相干断层扫描测量的中心黄斑厚度（CMT）、荧光素血管造影和OCTA（美国加利福尼亚州弗里蒙特市Optovue公司）。在治疗前后获得浅表毛细血管丛（SCP）和深层毛细血管丛血管密度的自动测量结果，并与年龄和性别匹配的健康受试者的结果进行比较。
分析了7例患者的7只眼（平均年龄76岁；57%为男性），包括3例中央RVO和4例分支RVO。所有患者均接受1次玻璃体内地塞米松植入物注射。平均随访2个月后，CMT平均从657 µm显著降至324 µm，BCVA从20/100提高到20/50（分别为p = 0.017和p<0.001）。在SCP，随访期间平均全层正面血管密度从43.21%略有下降至42.76%（无统计学意义）。血管密度在很大程度上低于对照组受试者（所有象限p≤0.01）。
本研究证实了OCTA作为一种新型无创成像技术的潜在作用，它能够对RVO黄斑水肿的随访进行定量和定性评估。光学相干断层扫描血管造影可以有利地补充多模态成像，以监测RVO患者。
