Shah Syed Raza, Alweis Richard, Shah Syed Arbab, Arshad Mohammad Hussham, Manji Adil Al-Karim, Arfeen Arham Amir, Javed Maheen, Shujauddin Syed Muhammad, Irfan Rida, Shabbir Sakina, Shaikh Shehryar
Department of Medicine, Dow University of Health Sciences (DUHS), Karachi, Pakistan;
Department of Internal Medicine, Reading Health System, West Reading, PA, USA.
J Community Hosp Intern Med Perspect. 2016 Jul 6;6(3):31957. doi: 10.3402/jchimp.v6.31957. eCollection 2016.
Colchicine, extracted from the colchicum autumnale plant, used by the ancient Greeks more than 20 centuries ago, is one of the most ancient drugs still prescribed even today. The major mechanism of action is binding to microtubules thereby interfering with mitosis and subsequent modulation of polymorphonuclear leukocyte function. Colchicine has long been of interest in the treatment of cardiovascular disease; however, its efficacy and safety profile for specific conditions have been variably established in the literature. In the subset of pericardial diseases, colchicine has been shown to be effective in recurrent pericarditis and post-pericardiotomy syndrome (PPS). The future course of treatment and management will therefore highly depend on the results of the ongoing large randomized placebo-controlled clinical trial to evaluate the efficacy and safety of colchicine for the primary prevention of several postoperative complications and in the perioperative period. Also, given the positive preliminary outcomes of colchicine usage in pericardial effusions, the future therapeutical use of colchicine looks promising. Further study is needed to clarify its role in these disease states, as well as explore other its role in other cardiovascular conditions.
秋水仙碱是从秋水仙植物中提取的，早在20多个世纪前就被古希腊人使用，它是至今仍在使用的最古老的药物之一。其主要作用机制是与微管结合，从而干扰有丝分裂并随后调节多形核白细胞功能。秋水仙碱长期以来一直用于治疗心血管疾病；然而，其在特定病症中的疗效和安全性在文献中尚未完全明确。在心包疾病的亚组中，秋水仙碱已被证明对复发性心包炎和心包切开术后综合征（PPS）有效。因此，未来的治疗和管理过程将高度依赖于正在进行的大型随机安慰剂对照临床试验的结果，以评估秋水仙碱在预防多种术后并发症及围手术期的疗效和安全性。此外，鉴于秋水仙碱在心包积液中的初步积极结果，秋水仙碱未来的治疗用途看起来很有前景。需要进一步研究以阐明其在这些疾病状态中的作用，以及探索其在其他心血管疾病中的作用。
