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通过糖原合酶激酶3β(GSK-3β)的再激活恢复肌丝功能:心脏再同步治疗的机制

Recovery of myofilament function through reactivation of glycogen synthase kinase 3β (GSK-3β): mechanism for cardiac resynchronization therapy.

作者信息

Shah Syed Raza, Fatima Kaneez, Ansari Mehreen

机构信息

Dow University of Health Sciences (DUHS), Karachi, Pakistan,

出版信息

J Interv Card Electrophysiol. 2014 Dec;41(3):193-4. doi: 10.1007/s10840-014-9939-2. Epub 2014 Sep 26.

DOI:10.1007/s10840-014-9939-2
PMID:25256801
Abstract

The burden of noncommunicable diseases (NCDs) is emerging as a major public health challenge for the world. NCDs are projected to account for around 75 % of global mortality by the year 2020. The most common and problematic of all noncommunicable conditions is heart disease. As such, the weight of evidence supporting the routine use of cardiac resynchronization therapy (CRT) as a fruitful treatment for patients with ventricular dyssynchrony and moderate to severe chronic systolic heart failure is now quite substantial. The recent study done by Kirk et al. adds to our understanding of the effects of CRT in treating heart failure patients. Whether the current observations and findings extend to the more common clinical situations remains to be determined.

摘要

非传染性疾病(NCDs)正成为全球主要的公共卫生挑战。预计到2020年,非传染性疾病将占全球死亡人数的75%左右。所有非传染性疾病中最常见且问题最大的是心脏病。因此,支持将心脏再同步治疗(CRT)作为治疗心室不同步和中度至重度慢性收缩性心力衰竭患者的有效治疗方法的证据现在相当充分。柯克等人最近进行的研究增进了我们对CRT治疗心力衰竭患者效果的理解。目前的观察结果和发现是否适用于更常见的临床情况仍有待确定。

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J Clin Invest. 2014 Jan;124(1):129-38. doi: 10.1172/JCI69253.
2
2013 ACCF/AHA guideline for the management of heart failure: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines.2013年美国心脏病学会基金会/美国心脏协会心力衰竭管理指南:执行摘要:美国心脏病学会基金会/美国心脏协会实践指南工作组报告
Circulation. 2013 Oct 15;128(16):1810-52. doi: 10.1161/CIR.0b013e31829e8807. Epub 2013 Jun 5.
3
Troponin phosphorylation and myofilament Ca2+-sensitivity in heart failure: increased or decreased?
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J Community Hosp Intern Med Perspect. 2018 Jun 12;8(3):101-106. doi: 10.1080/20009666.2018.1472513. eCollection 2018.
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Canakinumab and cardiovascular outcomes: results of the CANTOS trial.卡那单抗与心血管结局:CANTOS试验结果
J Community Hosp Intern Med Perspect. 2018 Feb 6;8(1):21-22. doi: 10.1080/20009666.2018.1428023. eCollection 2018.
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J Clin Diagn Res. 2017 Sep;11(9):OE05-OE07. doi: 10.7860/JCDR/2017/29473.10696. Epub 2017 Sep 1.
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Evolocumab to reduce cardiovascular events: results of the (FOURIER) multinational trial.依洛尤单抗降低心血管事件:(FOURIER)多国试验结果
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