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关节置换术后关节腔内注射布比卡因：一项随机安慰剂对照研究的系统评价和荟萃分析

Intra-articular bupivacaine after joint arthroplasty: a systematic review and meta-analysis of randomised placebo-controlled studies.

作者信息

Cui Yang, Yang Tuo, Zeng Chao, Wei Jie, Xie Xi, Li Liangjun, Ding Xiang, Zhang Yi, Lei Guanghua

机构信息

Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha, Hunan, China.

出版信息

BMJ Open. 2016 Jul 12;6(7):e011325. doi: 10.1136/bmjopen-2016-011325.

DOI:10.1136/bmjopen-2016-011325
PMID:27406643
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4947730/
Abstract

OBJECTIVES

To evaluate the efficacy and safety of intra-articular (IA) bupivacaine administered for pain relief after joint arthroplasty.

DESIGN

Meta-analysis.

METHODS

A systematic review was conducted to identify the randomised controlled trials using IA bupivacaine for postoperative pain relief from MEDLINE, Cochrane Library and EMBASE databases (up to October 2015). The standardised mean difference (SMD), the relative risk (RR) and their corresponding 95% CIs were calculated using the RevMan statistical software.

RESULTS

A total of 11 randomised controlled trials were included. Statistically significant differences between IA bupivacaine and placebo were observed for the mean visual analogue scale (VAS) values (SMD -0.55; 95% CI -0.89 to -0.22; p<0.001) and narcotic consumption (SMD -0.32; 95% CI -0.55 to -0.08; p=0.008) during the period of 24 hours postoperatively and narcotic consumption during the period between 24 and 48 hours postoperatively (SMD -0.32; 95% CI -0.55 to -0.08; p=0.009). However, there was no significant difference in the mean VAS pain score during the period between 24  and 48 hours postoperatively (SMD -0.09, 95% CI -0.30 to 0.11; p=0.37) and in the incidence of adverse effects 24-72 hours postoperatively (RR 0.97; 95% CI 0.60 to 1.57; p=0.91).

CONCLUSIONS

The administration of IA bupivacaine after joint arthroplasty is effective for pain relief without increasing adverse effects.

摘要

目的

评估关节腔内注射布比卡因用于关节置换术后疼痛缓解的有效性和安全性。

设计

荟萃分析。

方法

进行系统评价，以确定使用关节腔内注射布比卡因缓解术后疼痛的随机对照试验，检索MEDLINE、Cochrane图书馆和EMBASE数据库（截至2015年10月）。使用RevMan统计软件计算标准化均数差（SMD）、相对危险度（RR）及其相应的95%可信区间。

结果

共纳入11项随机对照试验。关节腔内注射布比卡因与安慰剂相比，术后24小时内的平均视觉模拟评分（VAS）值（SMD -0.55；95%可信区间 -0.89至-0.22；p<0.001）和麻醉药物消耗量（SMD -0.32；95%可信区间 -0.55至-0.08；p=0.008）以及术后24至48小时内的麻醉药物消耗量（SMD -0.32；95%可信区间 -0.55至-0.08；p=0.009）存在统计学显著差异。然而，术后24至48小时内的平均VAS疼痛评分（SMD -0.09，95%可信区间 -0.30至0.11；p=0.37）以及术后24 - 72小时内的不良反应发生率（RR 0.97；95%可信区间 0.60至1.57；p=0.91）无显著差异。

结论

关节置换术后注射关节腔内布比卡因可有效缓解疼痛且不增加不良反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c871/4947730/4e5bffbe8f66/bmjopen2016011325f10.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c871/4947730/e3ed366e4b7c/bmjopen2016011325f03.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c871/4947730/d78c6bea2c98/bmjopen2016011325f05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c871/4947730/5a61e760d8ed/bmjopen2016011325f06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c871/4947730/f3ac102d2414/bmjopen2016011325f07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c871/4947730/da63d76b129b/bmjopen2016011325f08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c871/4947730/5c33f3223c06/bmjopen2016011325f09.jpg
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1
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2
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3
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9
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10
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