Kim D, Yoon S-J, Lim D-S, Gong Y-H, Ko S, Lee Y-H, Lee H S, Park M-S, Kim K-H, Kim Y A
Department of Preventive Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
Department of Preventive Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
Public Health. 2016 Oct;139:178-182. doi: 10.1016/j.puhe.2016.06.012. Epub 2016 Jul 9.
Metabolic syndrome (MS), as a precursor of diabetes mellitus (DM) and cardiovascular disease, is increasing steadily worldwide. We examined the preventive effects of lifestyle intervention on the occurrence of DM and acute myocardial infarction (AMI) in MS.
Observational study on disease occurrence after lifestyle intervention.
The lifestyle intervention was administered to subjects with MS participating in a metropolitan lifestyle intervention program for 1 year. The same numbers of non-participating age- and sex-matched subjects with MS were randomly extracted from national health examination data. After intervention or examination, new occurrences of hypertension, DM, and AMI were identified through the national health insurance claims data during 1 year. For DM and AMI, multivariate logistic regression analysis for the factors affecting each disease was performed.
In the intervention group and the control group (14,918 in each group), the occurrence of hypertension was 555 (6.07%) and 751 (8.33%), the occurrence of DM was 324 (2.55%) and 488 (3.89%), the occurrence of dyslipidemia was 321 (2.59%) and 373 (2.72%), and the occurrence of AMI was 13 (0.09%) and 26 (0.17%), respectively. In multivariate logistic regression analysis, adjusted odds ratios for intervention were 0.752 (95% confidence interval [CI]: 0.644-0.879) and 0.499 (95% CI: 0.251-0.992) for DM and AMI, respectively, indicating that lifestyle intervention has a preventive effect.
Lifestyle intervention in MS has preventive effects on the occurrence of DM and AMI, and long-term follow-up is needed to evaluate these preventive effects in more detail.
代谢综合征（MS）作为糖尿病（DM）和心血管疾病的前驱疾病，在全球范围内正稳步增加。我们研究了生活方式干预对MS患者发生DM和急性心肌梗死（AMI）的预防作用。
关于生活方式干预后疾病发生情况的观察性研究。
对参与大城市生活方式干预项目1年的MS患者进行生活方式干预。从国家健康检查数据中随机抽取相同数量的未参与干预的年龄和性别匹配的MS患者。干预或检查后，通过1年期间的国家医疗保险理赔数据确定高血压、DM和AMI的新发病例。对于DM和AMI，对影响每种疾病的因素进行多因素逻辑回归分析。
干预组和对照组（每组14918例）中，高血压的发生率分别为555例（6.07%）和751例（8.33%），DM的发生率分别为324例（2.55%）和488例（3.89%），血脂异常的发生率分别为321例（2.59%）和373例（2.72%），AMI的发生率分别为13例（0.09%）和26例（0.17%）。在多因素逻辑回归分析中，DM和AMI的干预调整比值比分别为0.752（95%置信区间[CI]：0.644 - 0.879）和0.499（95%CI：0.251 - 0.992），表明生活方式干预具有预防作用。
MS患者的生活方式干预对DM和AMI的发生具有预防作用，需要进行长期随访以更详细地评估这些预防效果。
