Mathiew-Quirós Álvaro, Salinas-Martínez Ana María, Guzmán de la Garza Francisco Javier, Garza-Sagástegui María Guadalupe, Guzmán-Delgado Nancy Elena, Palmero-Hinojosa Magda Graciela, Oliva-Sosa Norma Edith
Unidad de Investigación Epidemiológica y en Servicios de Salud, Monterrey, N.L., México.
Jefatura de Servicios Médicos, Delegación Regional Nuevo León, Monterrey, N.L., México.
Gac Med Mex. 2017 May-Jun;153(3):297-304.
Acute coronary diseases are catastrophic, especially in young patients.
To determine the risk of metabolic syndrome (MS) for premature acute myocardial infarction (AMI), combined with familial, behavioral, and nutritional factors in the northeast of Mexico.
This is a case control study of patients less than 47 years of age with no personal history of angina, AMI, or cerebrovascular disease. Cases corresponded to patients with AMI (incident and primary cases; n = 55) and controls were blood donors located at the same hospital (n = 55). Behavioral, nutritional, and cardiometabolic risk factors were measured. Multivariate logistic regression was used for estimating odds ratios (OR) and 95% confidence intervals (95% CI).
MS increased the risk for premature AMI (95% CI: 1.73-39.5) eightfold, followed by smoking (OR: 7.76; 95% CI: 1.27-47.3), family history of AMI or sudden death (OR: 11.0; 95% CI: 2.03-60.4), and sedentary lifestyle (OR: 2.26; 95% CI: 2.52-9.80), independent of potential confounders.
The study highlights the magnitude of the risk of MS for AMI in Mexican young adults. The phenomenon of coronary diseases among young adults needs essential attention from the health sector.
急性冠状动脉疾病具有灾难性，尤其在年轻患者中。
结合墨西哥东北部的家族、行为和营养因素，确定代谢综合征（MS）导致早发急性心肌梗死（AMI）的风险。
这是一项病例对照研究，研究对象为年龄小于47岁且无心绞痛、AMI或脑血管疾病个人史的患者。病例为AMI患者（新发和原发性病例；n = 55），对照为同一医院的献血者（n = 55）。测量行为、营养和心脏代谢危险因素。采用多因素logistic回归估计比值比（OR）和95%置信区间（95%CI）。
MS使早发AMI风险增加8倍（95%CI：1.73 - 39.5），其次是吸烟（OR：7.76；95%CI：1.27 - 47.3）、AMI或猝死家族史（OR：11.0；95%CI：2.03 - 60.4）和久坐不动的生活方式（OR：2.26；95%CI：2.52 - 9.80），且不受潜在混杂因素影响。
该研究突出了墨西哥年轻成年人中MS导致AMI风险的严重程度。年轻人中的冠心病现象需要卫生部门给予必要关注。
