米索前列醇用于早期人工流产的辅助治疗。
Misoprostol as aid in First Trimester MTP.
作者信息
Vardhan Shakti, Behera R C, Sandhu G S, Goyal B K
机构信息
Associate Professor (Obstetrics and Gynaecology), AFMC, Pune-40.
Ex-Commandant, 167 MH.
出版信息
Med J Armed Forces India. 2006 Jan;62(1):14-5. doi: 10.1016/S0377-1237(06)80144-9. Epub 2011 Jul 21.
BACKGROUND
Medical Termination of Pregnancy (MTP) is a commonly performed during the first trimester. Dilatation and Evacuation (D & E) mandates rapid dilatation of cervix with metal dilators, which requires anaesthesia and may be associated with trauma to the uterus, cervix and later cervical incompetence. The problem of rapid cervical dilatation is obviated with intravaginal misoprostol.
METHODS
Intravaginal misoprostol tablet 200 microgram was inserted, a night prior to MTP to ripen the cervix. Cervix was dilated with metal dilators only in cases where cervix did not loosen up sufficiently. Products of conception were removed by suction.
RESULTS
Out of 108 cases cervical dilatation was not required in 96 cases (88.9%).
CONCLUSION
Intravaginal misoprostol 200 microgram proved effective as a priming agent prior to MTP in the first trimester.
背景
妊娠早期人工流产是一种常见的手术。扩张刮宫术（D&E）需要用金属扩张器快速扩张宫颈，这需要麻醉，并且可能会对子宫、宫颈造成创伤，进而导致后期宫颈机能不全。阴道内使用米索前列醇可避免快速宫颈扩张的问题。
方法
在人工流产前一晚，阴道内放置200微克米索前列醇片以使宫颈成熟。仅在宫颈未充分软化的情况下，才使用金属扩张器扩张宫颈。通过抽吸清除妊娠物。
结果
108例中，96例（88.9%）无需宫颈扩张。
结论
200微克阴道内米索前列醇被证明在妊娠早期人工流产前作为预处理药物是有效的。
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