Ngai S W, Yeung K C, Lao T, Ho P C
Department of Obstetrics and Gynaecology, University of Hong Kong, Tsan Yuk Hospital.
Contraception. 1995 Jun;51(6):347-50. doi: 10.1016/0010-7824(95)00099-v.
The effectiveness of oral misoprostol versus vaginal gemeprost for cervical dilatation prior to vacuum aspiration was compared in women in the 6th to 12th week of pregnancy. Sixty-four nulliparous women requesting termination of pregnancy between 6th to 12th weeks of gestation were randomized to receive either 400 micrograms misoprostol orally or 1 mg vaginal gemeprost at 12 hr or 3 hr prior to vacuum aspiration, respectively. The cervical dilatation at vacuum aspiration, the ease of the subsequent surgical procedure, and the incidence of complications and side effects were compared between these two methods of cervical priming. The median cervical dilatation at vacuum aspiration in the misoprostol group was significantly greater than that in the gemeprost group (8.0 mm versus 7.0 mm, p < 0.02). Preoperative side effects were significantly less frequent in the misoprostol group (p < 0.01). The ease of dilatation assessed subjectively by the operating surgeons was also improved significantly in the misoprostol group (p < 0.01). However, the duration of operation and blood loss were similar in both groups. Since misoprostol is also much cheaper and more convenient to use, we conclude that oral misoprostol is better than vaginal gemeprost for cervical dilatation prior to vacuum aspiration in first trimester pregnancy.
在妊娠第6至12周的女性中，比较了口服米索前列醇与阴道用吉美前列素在真空吸引术前扩张宫颈的效果。64名妊娠6至12周要求终止妊娠的未生育女性被随机分组，分别在真空吸引术前12小时或3小时口服400微克米索前列醇或阴道给予1毫克吉美前列素。比较了这两种宫颈预处理方法在真空吸引时的宫颈扩张情况、后续手术操作的难易程度以及并发症和副作用的发生率。米索前列醇组在真空吸引时的宫颈扩张中位数显著大于吉美前列素组（8.0毫米对7.0毫米，p<0.02）。米索前列醇组术前副作用的发生频率显著更低（p<0.01）。手术医生主观评估的扩张难易程度在米索前列醇组也有显著改善（p<0.01）。然而，两组的手术时间和失血量相似。由于米索前列醇也更便宜且使用更方便，我们得出结论，在孕早期真空吸引术前扩张宫颈方面，口服米索前列醇优于阴道用吉美前列素。
