Sylvia Mary Theresa, Jacob Sajini Elizabeth, Basu Debdatta, Amalnath Deepak, Dutta Tarun Kumar
Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Gorimedu, Puducherry, 605011 Puducherry India.
Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Gorimedu, Puducherry, 605011 Puducherry India.
Indian J Hematol Blood Transfus. 2016 Jun;32(Suppl 1):121-4. doi: 10.1007/s12288-015-0502-9. Epub 2015 Jan 13.
T cell large granular lymphocytic leukemia is a clonal proliferation of cytotoxic large granular T cells positive for CD3 and CD8. It is a chronic lymphoproliferative disorder with an indolent course. Therapeutic options include observation and low dose chemotherapy. Rarely, they have an aggressive course. Such cases have expression of NK cell associated antigens like CD56 in the T cells. These cases require more aggressive therapy with acute lymphoblastic leukemia regimens. We report a case of fatal CD56 negative T cell large granular lymphocytic leukemia in a 38 year old lady.
T细胞大颗粒淋巴细胞白血病是一种细胞毒性大颗粒T细胞的克隆性增殖，这些T细胞CD3和CD8呈阳性。它是一种病程缓慢的慢性淋巴细胞增殖性疾病。治疗选择包括观察和低剂量化疗。极少数情况下，其病程呈侵袭性。此类病例中T细胞表达NK细胞相关抗原，如CD56。这些病例需要采用急性淋巴细胞白血病治疗方案进行更积极的治疗。我们报告一例38岁女性致命性CD56阴性T细胞大颗粒淋巴细胞白血病病例。
