DNA损伤反应与修复数据以及Tousled的药理学调节剂
DNA damage response and repair data with pharmacological modulators of Tousled.
作者信息
Timiri Shanmugam Prakash Srinivasan, Nair Renjith P, DeBenedetti Arrigo, Caldito Gloria, Abreo Fleurette, Sunavala-Dossabhoy Gulshan
机构信息
Department of Biochemistry and Molecular Biology, USA.
Department of Computational Biology and Bioinformatics, USA.
出版信息
Data Brief. 2016 Mar 30;7:1073-7. doi: 10.1016/j.dib.2016.03.075. eCollection 2016 Jun.
Human Tousled kinase 1 (TLK1) plays an important role in chromatin remodeling, replication, and DNA damage response and repair. TLK1 activity is immediately, but transiently, downregulated after genotoxic insult, and its recovery is important for exit from checkpoint arrest and cell survival after radiation. The data in this article compliments research presented in the paper titled, "Tousled kinase activator, gallic acid, promotes DNA repair and suppresses radiation cytotoxicity in salivary gland cells" [1]. The identification of small molecule activators and inhibitors of TLK1 provided an opportunity to pharmacologically alter the protein׳s activity to elucidate its role in DNA damage response pathways. TLK1 effectors, gallic acid (GA) and thioridazine (THD) activate and inhibit the kinase, respectively, and the data report on the impact of these compounds and the significance of TLK1 to DNA break repair and the survival of human salivary acinar cells.
人类Tousled激酶1（TLK1）在染色质重塑、复制以及DNA损伤反应与修复过程中发挥着重要作用。在基因毒性损伤后，TLK1的活性会立即但短暂地下调，其恢复对于辐射后从检查点阻滞状态退出以及细胞存活至关重要。本文中的数据补充了题为《Tousled激酶激活剂没食子酸促进唾液腺细胞DNA修复并抑制辐射细胞毒性》[1]的论文中所呈现的研究。TLK1小分子激活剂和抑制剂的鉴定为从药理学角度改变该蛋白的活性以阐明其在DNA损伤反应途径中的作用提供了契机。TLK1效应物没食子酸（GA）和硫利达嗪（THD）分别激活和抑制该激酶，并且本文数据报道了这些化合物的影响以及TLK1对人类唾液腺腺泡细胞DNA断裂修复和存活的重要性。
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