Osawa Kentaro, Minemura Hiroyuki, Anzai Yumiko, Tomita Daisuke, Shimanaka Tetsuya, Suzuki Tomokazu, Iida Hiroki, Matsuura Naoya, Katagiri Chika, Yamashita Toyonobu, Hara Yusuke, Watanabe Koichi
Appl Opt. 2016 Jul 1;55(19):5052-6. doi: 10.1364/AO.55.005052.
We have demonstrated tomographic imaging of in vivo human skin with an optical interferometric imaging technique using a monochromatic light source. The axial resolution of this method is determined by the center wavelength and the NA of the objective and is irrelevant to the bandwidth of the light source in contrast to optical coherence tomography. Our imaging system is constructed with low-priced and small-sized compact disk optical pickup components, a laser diode, a high NA objective, and a voice coil actuator. In spite of its low cost and small size, our imaging system can visualize the structure of human skin as clearly as a commercial reflectance confocal microscope.
我们已经利用一种使用单色光源的光学干涉成像技术，展示了对活体人体皮肤的层析成像。与光学相干断层扫描不同，该方法的轴向分辨率由中心波长和物镜的数值孔径决定，与光源带宽无关。我们的成像系统由低价小型光盘光学拾取组件、激光二极管、高数值孔径物镜和音圈致动器构成。尽管成本低且尺寸小，但我们的成像系统能够像商用反射共聚焦显微镜一样清晰地显示人体皮肤的结构。
