Inoue Maiko, Jung Jesse J, Balaratnasingam Chandrakumar, Dansingani Kunal K, Dhrami-Gavazi Elona, Suzuki Mihoko, de Carlo Talisa E, Shahlaee Abtin, Klufas Michael A, El Maftouhi Adil, Duker Jay S, Ho Allen C, Maftouhi Maddalena Quaranta-El, Sarraf David, Freund K Bailey
Vitreous Retina Macula Consultants of New York, New York, New York, United States 2The LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, United States 3Yokohama City University Medical Center, Yokohama.
Vitreous Retina Macula Consultants of New York, New York, New York, United States 2The LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, United States 4Edward S. Harkness Eye Institute, Columbia Univers.
Invest Ophthalmol Vis Sci. 2016 Jul 1;57(9):OCT314-23. doi: 10.1167/iovs.15-18900.
To determine the sensitivity of the combination of optical coherence tomography angiography (OCTA) and structural optical coherence tomography (OCT) for detecting type 1 neovascularization (NV) and to determine significant factors that preclude visualization of type 1 NV using OCTA.
Multicenter, retrospective cohort study of 115 eyes from 100 patients with type 1 NV. A retrospective review of fluorescein (FA), OCT, and OCTA imaging was performed on a consecutive series of eyes with type 1 NV from five institutions. Unmasked graders utilized FA and structural OCT data to determine the diagnosis of type 1 NV. Masked graders evaluated FA data alone, en face OCTA data alone and combined en face OCTA and structural OCT data to determine the presence of type 1 NV. Sensitivity analyses were performed using combined FA and OCT data as the reference standard.
A total of 105 eyes were diagnosed with type 1 NV using the reference. Of these, 90 (85.7%) could be detected using en face OCTA and structural OCT. The sensitivities of FA data alone and en face OCTA data alone for visualizing type 1 NV were the same (66.7%). Significant factors that precluded visualization of NV using en face OCTA included the height of pigment epithelial detachment, low signal strength, and treatment-naïve disease (P < 0.05, respectively).
En face OCTA and structural OCT showed better detection of type 1 NV than either FA alone or en face OCTA alone. Combining en face OCTA and structural OCT information may therefore be a useful way to noninvasively diagnose and monitor the treatment of type 1 NV.
确定光学相干断层扫描血管造影（OCTA）与结构光学相干断层扫描（OCT）联合检测1型新生血管（NV）的敏感性，并确定妨碍使用OCTA观察1型NV的重要因素。
对100例患有1型NV的患者的115只眼进行多中心回顾性队列研究。对来自五个机构的一系列连续的1型NV患眼进行荧光素（FA）、OCT和OCTA成像的回顾性分析。未设盲的分级人员利用FA和结构OCT数据来确定1型NV的诊断。设盲的分级人员分别评估单独的FA数据、正面OCTA数据以及正面OCTA和结构OCT数据的组合，以确定1型NV的存在。使用联合FA和OCT数据作为参考标准进行敏感性分析。
使用参考标准共诊断出105只眼患有1型NV。其中，90只眼（85.7%）可通过正面OCTA和结构OCT检测到。单独的FA数据和单独的正面OCTA数据观察1型NV的敏感性相同（66.7%）。妨碍使用正面OCTA观察NV的重要因素包括色素上皮脱离的高度、低信号强度和未经治疗的疾病（P均<0.05）。
正面OCTA和结构OCT联合检测1型NV比单独使用FA或单独使用正面OCTA表现更好。因此，结合正面OCTA和结构OCT信息可能是一种无创诊断和监测1型NV治疗的有用方法。
