Key Laboratory of Radiopharmaceuticals, College of Chemistry, Beijing Normal University , Beijing 100875, China.
J Org Chem. 2016 Aug 5;81(15):6640-8. doi: 10.1021/acs.joc.6b01273. Epub 2016 Jul 27.
An enantioselective hydrogenation of N-substituted diarylmethanimines under mild conditions has been first realized by using an iridium catalyst with a chiral f-spiroPhos ligand. This method provides an efficient access to the asymmetric synthesis of a variety of chiral diarylmethylamines and their derivatives with excellent enantioselectivities (up to 99.4% ee) and high turnover numbers (TON up to 4000).
手性 f-spiroPhos 配体铱催化剂的在手性 N-取代二芳基甲亚胺的温和条件下的对映选择性氢化反应首次被实现。该方法为各种手性二芳基甲基胺及其衍生物的不对称合成提供了有效途径，具有优异的对映选择性（高达 99.4%ee）和高周转数（TON 高达 4000）。
