Zhang Ying, Kong Duanyang, Wang Rui, Hou Guohua
Key Laboratory of Radiopharmaceuticals, College of Chemistry, Beijing Normal University, No. 19 Xinjiekouwai St., Beijing 100875, China.
Org Biomol Chem. 2017 Apr 5;15(14):3006-3012. doi: 10.1039/c7ob00442g.
A highly enantioselective hydrogenation of cyclic imines for synthesis of chiral cyclic amines has been realized. With the complex of iridium and (R,R)-f-spiroPhos as the catalyst, a range of cyclic 2-aryl imines were smoothly hydrogenated under mild conditions without any additive to provide the corresponding chiral cyclic amines with excellent enantioselectivities of up to 98% ee. Moreover, this method could be successfully applied to the synthesis of (+)-(6S,10bR)-McN-4612-Z.
实现了用于合成手性环胺的环状亚胺的高度对映选择性氢化反应。以铱与(R,R)-f-螺环膦的配合物为催化剂，一系列环状2-芳基亚胺在温和条件下无需任何添加剂即可顺利氢化，以高达98% ee的优异对映选择性提供相应的手性环胺。此外，该方法可成功应用于(+)-(6S,10bR)-McN-4612-Z的合成。
