[Mast-cell mechanism of the pathogenesis of bronchial asthma and peroxidation of membrane lipids].

Examination of 155 patients with atopic, infection-dependent bronchial asthma (BA) and chronic asthmatic bronchitis in the phase of the disease exacerbation and remission has shown that hyperhistaminemia is common not only to atopic but also to infection-dependent BA. It is established that activation of lipid peroxidation of the membranes more pronounced during exacerbation and attacks of asthma is one of the most important alternative mechanisms of mast cell activation, that is supported by the data of experimental morphologic and biochemical studies of the effect exerted by peroxidized fatty acids on histamine liberation and mast cell degranulation.