不同种族中编码HLA - B5和B35交叉反应组抗原的基因的保守性。

Conservation of genes encoding HLA-B5 and B35 cross-reactive group antigens in various races.

作者信息

Kato N, Ward F, Kano K, Takiguchi M

机构信息

Department of Tumor Biology and Immunology, University of Tokyo, Japan.

出版信息

Hum Immunol. 1992 Dec;35(4):253-5. doi: 10.1016/0198-8859(92)90007-a.

DOI:10.1016/0198-8859(92)90007-a

PMID:1293089

Abstract

HLA-B5 and B35 CREG antigens include HLA-B35, B51, B52, B53, and B78. Recent studies suggest that the genes encoding the HLA-B5, B35 CREG, and HLA-B58 antigens share a common ancestor. We sequenced the exons of the genes encoding HLA-B51, B53, and B58 from American black individuals and the gene HLA-B52 encoding from an Arabic individual, and compared them with previously reported sequences of HLA-B51 (B5101) and HLA-B52 (B5201) from Japanese, HLA-B53 (B5301) from an Algerian, and HLA-B58 (B5801) from a Sardinian. The sequences of the genes from the American black and Arabic individuals were identical to those from the other races. These findings support the hypothesis that these antigens have evolved prior to divergence of the major ethnic groups.

摘要

HLA - B5和B35复合相关抗原包括HLA - B35、B51、B52、B53和B78。最近的研究表明，编码HLA - B5、B35复合相关抗原和HLA - B58抗原的基因有着共同的祖先。我们对来自美国黑人个体的编码HLA - B51、B53和B58的基因外显子以及来自一名阿拉伯个体的编码HLA - B52的基因进行了测序，并将它们与先前报道的来自日本人的HLA - B51（B5101）和HLA - B52（B5201）、来自一名阿尔及利亚人的HLA - B53（B5301）以及来自一名撒丁岛人的HLA - B58（B5801）的序列进行了比较。来自美国黑人和阿拉伯个体的基因序列与来自其他种族的序列相同。这些发现支持了这样一种假说，即这些抗原在主要种族分化之前就已经进化了。