Chin A, Gill M A, Ito M K, Yellin A E, Berne T V, Heseltine P N, Appleman M D, Chenella F C
School of Pharmacy, University of Southern California, Los Angeles County.
Ther Drug Monit. 1989;11(4):421-4.
The study objective was to evaluate serum, peritoneal fluid, and appendix tissue concentrations of clindamycin using two differing clindamycin regimens. Patients age 16 years and older who were about to undergo appendectomies were randomly assigned to receive gentamicin 1.5 mg/kg every 8 h admixed with clindamycin 900 mg every 8 h (8-h group) or clindamycin 600 mg every 6 h given separately (6-h group). Doses of each regimen were given preoperatively. Serum, peritoneal fluid, and appendix tissue samples were obtained intraoperatively, and frozen at -70 degrees C for gas chromatographic drug analysis. Twenty-one patients were evaluated, 11 patients in the 8-h group and 10 patients in the 6-h group. Values are reported as means +/- standard deviations. The values in the 8-h group were 12.3 +/- 14.1 micrograms/ml, 8.7 +/- 3.9 micrograms/ml, and 9.8 +/- 10.3 micrograms/g for serum, peritoneal fluid, and appendix tissue, respectively. The values in the 6-h group were 9.7 +/- 5.1 micrograms/ml, 5.8 +/- 5.3 micrograms/ml, and 6.2 +/- 4.9 micrograms/g for serum, peritoneal fluid, and appendix tissue, respectively. The 6-h group received more doses preoperatively (1.8 +/- 0.6) than the 8-h group (1.2 +/- 0.4; p less than 0.05). No differences in penetration of clindamycin into the serum, peritoneal fluid, and appendix tissue for the 8-h group and the 6-h group were noted. The study revealed a similarity in penetration of clindamycin into the serum, peritoneal fluid, and appendix tissue using either clindamycin 900 mg given by intermittent intravenous infusion every 8 h admixed with gentamicin or clindamycin 600 mg given every 6-h separately.
本研究的目的是使用两种不同的克林霉素给药方案，评估血清、腹腔液和阑尾组织中克林霉素的浓度。16岁及以上即将接受阑尾切除术的患者被随机分配，每8小时接受1.5mg/kg庆大霉素与每8小时900mg克林霉素混合给药（8小时组），或每6小时单独给予600mg克林霉素（6小时组）。每种方案的剂量均在术前给予。术中采集血清、腹腔液和阑尾组织样本，并在-70℃冷冻，用于气相色谱药物分析。共评估了21例患者，8小时组11例，6小时组10例。数值以平均值±标准差表示。8小时组血清、腹腔液和阑尾组织中的数值分别为12.3±14.1μg/ml、8.7±3.9μg/ml和9.8±10.3μg/g。6小时组血清、腹腔液和阑尾组织中的数值分别为9.7±5.1μg/ml、5.8±5.3μg/ml和6.2±4.9μg/g。6小时组术前接受的剂量（1.8±0.6）比8小时组（1.2±0.4）多（p<0.05）。8小时组和6小时组在克林霉素渗透到血清、腹腔液和阑尾组织方面未发现差异。该研究表明，每8小时间歇静脉输注900mg克林霉素与庆大霉素混合使用，或每6小时单独给予600mg克林霉素，在克林霉素渗透到血清、腹腔液和阑尾组织方面具有相似性。
