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电磁烟雾与自身免疫性疾病。

Electrosmog and autoimmune disease.

作者信息

Marshall Trevor G, Heil Trudy J Rumann

机构信息

Autoimmunity Research Foundation, Thousand Oaks, CA, USA.

NP-Private Practice Associates, Scottsdale, AZ, USA.

出版信息

Immunol Res. 2017 Feb;65(1):129-135. doi: 10.1007/s12026-016-8825-7.

DOI:10.1007/s12026-016-8825-7
PMID:27412293
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5406447/
Abstract

Studies in mice have shown that environmental electromagnetic waves tend to suppress the murine immune system with a potency similar to NSAIDs, yet the nature of any Electrosmog effects upon humans remains controversial. Previously, we reported how the human Vitamin-D receptor (VDR) and its ligand, 1,25-dihydroxyvitamin-D (1,25-D), are associated with many chronic inflammatory and autoimmune diseases. We have shown how olmesartan, a drug marketed for mild hypertension, acts as a high-affinity partial agonist for the VDR, and that it seems to reverse disease activity resulting from VDR dysfunction. We here report that structural instability of the activated VDR becomes apparent when observing hydrogen bond behavior with molecular dynamics, revealing that the VDR pathway exhibits a susceptibility to Electrosmog. Further, we note that characteristic modes of instability lie in the microwave frequency range, which is currently populated by cellphone and WiFi communication signals, and that the susceptibility is ligand dependent. A case series of 64 patient-reported outcomes subsequent to use of a silver-threaded cap designed to protect the brain and brain stem from microwave Electrosmog resulted in 90 % reporting "definite" or "strong" changes in their disease symptoms. This is much higher than the 3-5 % rate reported for electromagnetic hypersensitivity in a healthy population and suggests that effective control of environmental Electrosmog immunomodulation may soon become necessary for successful therapy of autoimmune disease.

摘要

对小鼠的研究表明,环境电磁波往往会抑制小鼠免疫系统,其效力与非甾体抗炎药相似,但关于电烟雾对人类的任何影响的本质仍存在争议。此前,我们报道了人类维生素D受体(VDR)及其配体1,25 - 二羟基维生素D(1,25 - D)如何与许多慢性炎症和自身免疫性疾病相关联。我们已经表明,一种用于治疗轻度高血压的药物奥美沙坦,可作为VDR的高亲和力部分激动剂,并且它似乎能逆转由VDR功能障碍导致的疾病活动。我们在此报告,当通过分子动力学观察氢键行为时,活化的VDR的结构不稳定性变得明显,这表明VDR途径对电烟雾敏感。此外,我们注意到不稳定的特征模式处于微波频率范围内,目前该频率范围被手机和WiFi通信信号占据,并且这种敏感性是依赖配体的。一系列64例患者报告的结果显示,在使用旨在保护大脑和脑干免受微波电烟雾影响的银线帽之后,90%的患者报告其疾病症状有“明确”或“强烈”的变化。这远高于健康人群中报告的电磁超敏反应3 - 5%的发生率,表明对于自身免疫性疾病的成功治疗,有效控制环境电烟雾免疫调节可能很快就变得必要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d58a/5406447/13356641e182/12026_2016_8825_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d58a/5406447/ffd4af260f0f/12026_2016_8825_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d58a/5406447/c683a95afd4f/12026_2016_8825_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d58a/5406447/8f6536110ba0/12026_2016_8825_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d58a/5406447/614b4f73c76c/12026_2016_8825_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d58a/5406447/2834e936f6ad/12026_2016_8825_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d58a/5406447/a16f1969da52/12026_2016_8825_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d58a/5406447/13356641e182/12026_2016_8825_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d58a/5406447/ffd4af260f0f/12026_2016_8825_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d58a/5406447/c683a95afd4f/12026_2016_8825_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d58a/5406447/8f6536110ba0/12026_2016_8825_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d58a/5406447/614b4f73c76c/12026_2016_8825_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d58a/5406447/2834e936f6ad/12026_2016_8825_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d58a/5406447/a16f1969da52/12026_2016_8825_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d58a/5406447/13356641e182/12026_2016_8825_Fig7_HTML.jpg

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