Yi Biyu, Pei Yijin, Wang Chun, Jiang Yang
Department of Physiology, Guangdong Medical College, Dongguan 523808, China.
Department of Physiology, Guangdong Medical College, Dongguan 523808, China. *Corresponding author, E-mail: 1162330737@@qq.com.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016 Aug;32(8):1099-104.
Objective To investigate the potential association of cytotoxic T lymphocyte associated protein 4 (CTLA4) polymorphisms with non-Hodgkin's lymphoma (NHL) risk. Methods Two reviewers independently searched the PubMed, MEDLINE, China National Knowledge Infrastructure (CNKI), Chinese WanFang databases and Database of Chinese Scientific and Technical Periodicals (VIP) for relevant studies from January 1, 1990 to May 25, 2016. Odds ratios (OR) with 95% confidence intervals (CI) for CTLA4 polymorphism and HNL risk were used to evaluate the strength of association. Meta-analysis was performed using SATA (v12.0) software. Results A total of 6 case-control studies concerning the CTLA4 +49A/G, -318T/C, and CT60A/G polymorphisms were included in the meta-analysis. The polymorphisms of the three alleles were not associated with genetic susceptibility to NHL (PZ>0.05 or 95%CI contains 1). In the subgroup analysis of CTLA4 +49A/G gene polymorphism, we found that AA was a risk factor for mixed type lymphoma (AA vs GG: OR=4.181, 95%CI: 1.362-12.833; AA+AG vs GG: OR=3.217, 95%CI: 1.055-9.810; AA vs AG+GG: OR=2.827, 95%CI: 1.345-5.940), but was a protect factor for B cell lymphoma (AA vs GG: OR=0.465, 95%CI: 0.251-0.863; AA vs AG+GG: OR=0.534, 95%CI: 0.362-0.788); AA was a risk factor in Italians (AA vs GG: OR=4.181, 95%CI: 1.362-12.833; AA+AG vs GG: OR=3.217, 95%CI: 1.055-9.810; AA vs AG+GG: OR=2.827, 95%CI: 1.345-5.940), but was a protect factor in Chinese (AA vs GG: OR=0.643, 95%CI: 0.417-0.992; AA vs AG+GG, OR=0.601, 95%CI: 0.395-0.913). Conclusion This meta-analysis suggests that the polymorphisms of the three alleles are not associated with genetic susceptibility to NHL.
目的 探讨细胞毒性T淋巴细胞相关蛋白4（CTLA4）基因多态性与非霍奇金淋巴瘤（NHL）发病风险的潜在关联。方法 两名研究者独立检索了PubMed、MEDLINE、中国知网（CNKI）、中文万方数据库及维普中文科技期刊数据库，收集1990年1月1日至2016年5月25日期间的相关研究。采用CTLA4基因多态性与HNL发病风险的比值比（OR）及95%置信区间（CI）评估关联强度。使用SATA（v12.0）软件进行荟萃分析。结果 共有6项关于CTLA4 +49A/G、-318T/C及CT60A/G基因多态性的病例对照研究纳入荟萃分析。这三个等位基因的多态性与NHL的遗传易感性无关（P>0.05或95%CI包含1）。在CTLA4 +49A/G基因多态性的亚组分析中，发现AA是混合型淋巴瘤的危险因素（AA与GG比较：OR=4.181，95%CI：1.362-12.833；AA+AG与GG比较：OR=3.217，95%CI：1.055-9.810；AA与AG+GG比较：OR=2.827，95%CI：1.345-5.940），但却是B细胞淋巴瘤的保护因素（AA与GG比较：OR=0.465，95%CI：0.251-0.863；AA与AG+GG比较：OR=0.534，95%CI：0.362-0.788）；在意大利人群中AA是危险因素（AA与GG比较：OR=4.181，95%CI：1.362-12.833；AA+AG与GG比较：OR=3.217，95%CI：1.055-
