细胞毒性T淋巴细胞抗原4 +49A/G多态性与癌症风险的关联：一项更新的荟萃分析。

Association of cytotoxic T lymphocyte antigen-4 +49A/G polymorphism and cancer risk: An updated meta-analysis.

作者信息

Gao Xueren, Zhang Shulong, Qiao Xiaoliang, Yao Yao, Wang Limin, Dong Dong, Ma Xinxiu, Wang Taosheng

机构信息

Department of Microbiology and Immunology, Medical College of Southeast University, Nanjing, Jiangsu, China.

Department of General Surgery, Zhongda Hospital, Southeast University Medical School, Nanjing, Jiangsu, China.

出版信息

Cancer Biomark. 2014;14(4):287-94. doi: 10.3233/CBM-140403.

DOI:10.3233/CBM-140403

PMID:24934372

Abstract

BACKGROUND

Associations between cytotoxic T lymphocyte antigen-4 (CTLA-4) +49A/G polymorphism and cancer risk are inconclusive. We performed this meta-analysis to derive a more precise estimation of the relationship.

METHODS

A comprehensive literature search was performed using electronic databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association.

RESULTS

A total of 16,358 cases and 19,737 controls from 46 studies were included. Overall, significant association between CTLA-4 +49A/G polymorphism and cancer risk was observed in all genetic models (G vs. A: OR=0.88, 95%CI=0.83-0.93, PH=0.000; GA vs. AA: OR=0.87, 95%CI=0.79-0.97, PH=0.000; GG vs. AA: OR=0.75, 95%CI= 0.65-0.86, PH=0.000; GG vs. GA+AA: OR=0.84, 95%CI=0.79-0.91, PH=0.001; GG+GA vs. AA: OR=0.83, 95%CI=0.74-0.92, PH=0.000). Stratified analysis by cancer type revealed that the CTLA-4+49A/G polymorphism is associated with the decreased risk of cervical cancer, breast cancer, lung cancer, HCC. Further subgroup analysis by ethnicity indicated that there was a statistically decreased cancer risk in Asian population.

CONCLUSION

This meta-analysis suggests that CTLA-4+49A/G polymorphism is associated with cancer risk, especially in Asian population.

摘要

背景

细胞毒性T淋巴细胞抗原4（CTLA-4）+49A/G多态性与癌症风险之间的关联尚无定论。我们进行了这项荟萃分析，以更精确地评估二者之间的关系。

方法

使用电子数据库进行全面的文献检索。采用比值比（OR）及95%置信区间（CI）评估关联强度。

结果

共纳入46项研究中的16358例病例和19737例对照。总体而言，在所有遗传模型中均观察到CTLA-4 +49A/G多态性与癌症风险之间存在显著关联（G与A相比：OR = 0.88，95%CI = 0.83 - 0.93，P值 = 0.000；GA与AA相比：OR = 0.87，95%CI = 0.79 - 0.97，P值 = 0.000；GG与AA相比：OR = 0.75，95%CI = 0.65 - 0.86，P值 = 0.000；GG与GA + AA相比：OR = 0.84，95%CI = 0.79 - 0.91，P值 = 0.001；GG + GA与AA相比：OR = 0.83，95%CI = 0.74 - 0.92，P值 = 0.000）。按癌症类型进行的分层分析显示，CTLA-4 +49A/G多态性与宫颈癌、乳腺癌、肺癌、肝癌风险降低相关。按种族进行的进一步亚组分析表明，亚洲人群的癌症风险在统计学上有所降低。