Sako F B, Traoré F A, Camara M K, Sylla M, Bangoura E F, Baldé O
Service des maladies infectieuses et tropicales, hôpital national Donka, Conakry, République de Guinée, Université Gamal Abdel Nasser de Conakry, BP 1147 Conakry, République de Guinée, Kipé, rue 177 Kakimbo, commune de Ratoma, BP 5845, Conakry, République de Guinée.
Service des maladies infectieuses et tropicales, hôpital national Donka, Conakry, République de Guinée, Faculté de médecine, pharmacie, odontostomatologie, université Gamal-Abdel-Nasser, BP 1147 Conakry, République de Guinée.
Med Sante Trop. 2016 May 1;26(2):199-202. doi: 10.1684/mst.2016.0554.
Cholera is an epidemic diarrheal disease transmitted through the digestive tract; it can cause obstetric complications in pregnant women. The objective of this study was to describe the epidemiological, clinical, and therapeutic aspects of cholera in pregnant women, as well as its course, during the 2012 epidemic in Conakry. This retrospective, descriptive studied examined the records of this epidemic over a 7-month period (from May 15 to December 15, 2012). Of 2,808 cholera patients at our hospital, 80 were pregnant, that is, 2.85%. Their mean age was 30 years [range: 15-45 years], 94% were from Conakry (94%), and 69% were in the third trimester of pregnancy. Choleriform diarrhea and vomiting were the main signs, found respectively in 100% and 95% of the women; dehydration was mild for 16%, moderate for 45%, and severe for 39%. Support consisted of rehydration, by plans A (16%), B (45%) or C (39%) and antibiotic treatment based on erythromycin (85%), doxycycline (14%), or azithromycin (1%). Other drugs that were used included phloroglucinol-trimethylphloroglucinol (Spasfon(®)) for 45%, acetaminophen for 65%, and iron/folic acid for 1% of cases. The major obstetric complications were 4 intrauterine deaths (5%), 2 cases of threatened abortion (2%), 1 preterm delivery (1%), and 1 maternal death. The cholera outbreak in 2012 affected a large number of pregnant women in Conakry, most during their third trimester. The classic clinical manifestations were associated with obstetric complications and maternal-fetal risks.
霍乱是一种经消化道传播的流行性腹泻疾病；它可导致孕妇出现产科并发症。本研究的目的是描述2012年科纳克里霍乱疫情期间孕妇霍乱的流行病学、临床和治疗方面情况及其病程。这项回顾性描述性研究检查了该疫情7个月期间（2012年5月15日至12月15日）的记录。在我院的2808例霍乱患者中，80例为孕妇，即占2.85%。她们的平均年龄为30岁[范围：15 - 45岁]，94%来自科纳克里，69%处于妊娠晚期。霍乱样腹泻和呕吐是主要症状，分别在100%和95%的女性中出现；16%为轻度脱水，45%为中度脱水，39%为重度脱水。支持治疗包括按方案A（16%）、B（45%）或C（39%）进行补液以及基于红霉素（85%）、强力霉素（14%）或阿奇霉素（1%）的抗生素治疗。使用的其他药物包括45%的病例使用了间苯三酚 - 三甲基间苯三酚（斯帕丰（®））、65%的病例使用了对乙酰氨基酚、1%的病例使用了铁/叶酸。主要产科并发症包括4例宫内死亡（5%）、2例先兆流产（2%）、1例早产（1%）和1例孕产妇死亡。2012年的霍乱疫情影响了科纳克里大量孕妇，大多数处于妊娠晚期。典型临床表现与产科并发症及母婴风险相关。
