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[微创板层角膜移植术的更新:DMEK、DSAEK和DALK]

[Update Minimally Invasive Lamellar Keratoplasty: DMEK, DSAEK and DALK].

作者信息

Cursiefen C, Schaub F, Bachmann B O

机构信息

Zentrum für Augenheilkunde, Universitätsklinikum Köln.

出版信息

Klin Monbl Augenheilkd. 2016 Sep;233(9):1033-42. doi: 10.1055/s-0041-110448. Epub 2016 Jul 14.

DOI:10.1055/s-0041-110448
PMID:27414243
Abstract

BACKGROUND

The spectrum of operative interventions in corneal disorders requiring keratoplasty has been expanded considerably in recent years. In addition to the standard technique with full-thickness replacement of the cornea (perforating keratoplasty), lamellar techniques have been introduced. The aim of this review is to highlight current opportunities, indications and complications, as well as possible strategies to standardise lamellar keratoplasties.

MATERIALS AND METHODS

Our own data and a review of the literature in PubMed are summarised.

RESULTS

Performing "Descemet Membrane Endothelial Keratoplasty" (DMEK), "Descemt Stripping Automated Endothelial Keratoplasty" (DSAEK) and "Deep Anterior Lamellar Keratoplasty" (DALK) can provide patients with disorders of the corneal endothelium or the anterior corneal stroma with minimally invasive corneal grafts at a reduced risk of complications.

CONCLUSION

DMEK and DSAEK are now internationally the surgical methods of choice in patients with endothelial corneal pathologies, i.e. in Fuchs' Endothelial Dystrophy. The DALK technique for lamellar replacement of the anterior stroma, i.e. in keratoconus, needs further standardisation, so that DALK can in future be performed more often even in less specialised departments. Major advantages of lamellar keratoplasties are the very good results in visual outcome and fewer immune reactions or graft rejections. Even intraoperative complications are rare. In the long term, further strategies are desirable for the standardisation of lamellar keratoplasties and its establishment as the primary standard procedure.

摘要

背景

近年来,需要角膜移植的角膜疾病的手术干预范围已大幅扩大。除了角膜全层置换的标准技术(穿透性角膜移植术)外,还引入了板层技术。本综述的目的是强调当前的机会、适应症和并发症,以及使板层角膜移植标准化的可能策略。

材料与方法

总结了我们自己的数据以及对PubMed文献的综述。

结果

进行“Descemet膜内皮角膜移植术”(DMEK)、“Descemet剥离自动内皮角膜移植术”(DSAEK)和“深前板层角膜移植术”(DALK)可为角膜内皮或前角膜基质疾病患者提供微创角膜移植,且并发症风险降低。

结论

目前,在国际上,DMEK和DSAEK是角膜内皮病变患者(即Fuchs内皮营养不良患者)的首选手术方法。用于前基质板层置换的DALK技术,即圆锥角膜患者的手术方法,需要进一步标准化,以便未来即使在不太专业的科室也能更频繁地进行DALK手术。板层角膜移植的主要优点是视觉效果非常好,免疫反应或移植排斥反应较少。甚至术中并发症也很少见。从长远来看,需要进一步的策略来使板层角膜移植标准化并将其确立为主要的标准手术。

相似文献

1
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Klin Monbl Augenheilkd. 2016 Sep;233(9):1033-42. doi: 10.1055/s-0041-110448. Epub 2016 Jul 14.
2
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Immune reactions after modern lamellar (DALK, DSAEK, DMEK) versus conventional penetrating corneal transplantation.现代板层角膜移植术(DALK、DSAEK、DMEK)与传统穿透性角膜移植术后的免疫反应。
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How Much Progress Has Been Made in Corneal Transplantation?角膜移植取得了多大进展?
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Five Keratoplasties From One Donor Cornea.来自一个供体角膜的五次角膜移植手术。
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Descemet Membrane Endothelial Keratoplasty for Graft Failure After Descemet Stripping Endothelial Keratoplasty: Clinical Results and Histopathologic Findings.Descemet 膜内皮角膜移植治疗撕囊式内皮角膜移植术后移植失败:临床结果和组织病理学发现。
JAMA Ophthalmol. 2015 Jul;133(7):813-9. doi: 10.1001/jamaophthalmol.2015.0906.

引用本文的文献

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[Patient- and donor-dependent factors in descemet membrane endothelial keratoplasty and their impact on visual acuity and quality of life].[角膜后弹力层内皮角膜移植术中患者及供体相关因素及其对视力和生活质量的影响]
Ophthalmologie. 2025 May 13. doi: 10.1007/s00347-025-02238-2.
2
Descemet's membrane endothelial keratoplasty is the predominant keratoplasty procedure in Germany since 2016: a report of the DOG-section cornea and its keratoplasty registry.2016 年以来,德美膜内皮角膜移植术成为德国主要的角膜移植术式:德国眼库协会角膜及其角膜移植登记处报告。
Br J Ophthalmol. 2024 May 21;108(5):646-653. doi: 10.1136/bjo-2022-323162.
3
[Descemet membrane endothelial keratoplasty in complex eyes].
[复杂眼的后弹力层内皮角膜移植术]
Ophthalmologe. 2019 Mar;116(3):228-235. doi: 10.1007/s00347-018-0818-6.
4
[Technique of Descemet membrane endothelial keratoplasty (DMEK) : Video article].[Descemet 膜内皮角膜移植术(DMEK)技术:视频文章]
Ophthalmologe. 2018 Sep;115(9):778-784. doi: 10.1007/s00347-018-0743-8.
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Treatment of anterior corneal scarring, following DSAEK graft failure, with combined graft exchange and phototherapeutic keratectomy.在角膜内皮移植术(DSAEK)移植失败后,采用联合移植置换和光动力角膜切削术治疗角膜前部瘢痕形成。
Eye Vis (Lond). 2017 May 4;4:12. doi: 10.1186/s40662-017-0078-6. eCollection 2017.