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[Descemet膜内皮角膜移植术(DMEK)和Descemet剥脱自动内皮角膜移植术(DSAEK)并发症的预防与处理]

[Prevention and management of complications in Descemet membrane endothelial keratoplasty (DMEK) and Descemet stripping automated endothelial keratoplasty (DSAEK)].

作者信息

Cursiefen C, Steven P, Roters S, Heindl L M

机构信息

Universitätsaugenklinik Köln, Universität zu Köln, Kerpener Str. 62, 50924, Köln, Deutschland.

出版信息

Ophthalmologe. 2013 Jul;110(7):614-21. doi: 10.1007/s00347-012-2679-8.

DOI:10.1007/s00347-012-2679-8
PMID:23740158
Abstract

BACKGROUND

Posterior lamellar keratoplasty, in the form of Descemet membrane endothelial keratoplasty (DMEK) and Descemet stripping automated endothelial keratoplasty (DSAEK), has become a standard procedure for therapy of endothelial diseases of the cornea. The aim of this article is to describe strategies to prevent and manage complications in DMEK and DSAEK surgery.

METHODS

The article is based on a PubMed literature search and own clinical data. Key words used were "DMEK", "DSAEK", "Descemet membrane endothelial keratoplasty" and "Descemet stripping automated endothelial keratoplasty".

RESULTS

The DMEK and DSAEK procedures are safe surgical strategies for treating endothelial corneal diseases if the indications are made correctly.

CONCLUSIONS

The DMEK procedure is the standard procedure for improvement of visual acuity especially for younger patients with Fuchs' dystrophy and DSAEK is particularly suitable for eyes with complicated anterior chamber situations.

摘要

背景

后弹力层角膜移植术,以 Descemet 膜内皮角膜移植术(DMEK)和 Descemet 膜剥除自动内皮角膜移植术(DSAEK)的形式,已成为治疗角膜内皮疾病的标准手术方法。本文旨在描述 DMEK 和 DSAEK 手术中预防和处理并发症的策略。

方法

本文基于 PubMed 文献检索和自身临床数据。使用的关键词为“DMEK”“DSAEK”“Descemet 膜内皮角膜移植术”和“Descemet 膜剥除自动内皮角膜移植术”。

结果

如果适应证选择正确,DMEK 和 DSAEK 手术是治疗角膜内皮疾病的安全手术策略。

结论

DMEK 手术是提高视力的标准手术方法,尤其适用于年轻的 Fuchs 角膜内皮营养不良患者,而 DSAEK 特别适用于前房情况复杂的眼睛。

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Br J Ophthalmol. 2024 May 21;108(5):646-653. doi: 10.1136/bjo-2022-323162.
2
[10 years of Descemet membrane endothelial keratoplasty in Fuchs endothelial corneal dystrophy : What have we learned?].[富克斯内皮性角膜营养不良患者行后弹力层内皮角膜移植术10年:我们学到了什么?]
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本文引用的文献

1
[Immune reactions after DMEK, DSAEK and DALK].[角膜内皮移植术(DMEK)、深板层角膜内皮移植术(DSAEK)和准分子激光角膜切削术(DALK)后的免疫反应]
Klin Monbl Augenheilkd. 2013 May;230(5):494-9. doi: 10.1055/s-0032-1328257. Epub 2013 Feb 27.
2
[Descemetectomy as therapy option for visually disturbing roll in Descemet's membrane].[角膜后弹力层切除术作为治疗角膜后弹力层视觉干扰性褶皱的治疗选择]
Ophthalmologe. 2013 Sep;110(9):872-5. doi: 10.1007/s00347-012-2761-2.
3
Descemet membrane endothelial keratoplasty: the taming of the shrew.Descemet膜内皮角膜移植术:驯服悍妇。 (此标题有一定隐喻性,“悍妇”可能暗指该手术中面临的棘手情况等,具体含义需结合文献内容理解 )
用于角膜内皮功能衰竭的后弹力层内皮角膜移植术(DMEK)与后弹力层剥除自动内皮角膜移植术(DSAEK)的比较
Cochrane Database Syst Rev. 2018 Jun 25;6(6):CD012097. doi: 10.1002/14651858.CD012097.pub2.
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Impact of Microscope-Integrated OCT on Ophthalmology Resident Performance of Anterior Segment Surgical Maneuvers in Model Eyes.显微镜集成光学相干断层扫描对眼科住院医师在模型眼中进行眼前段手术操作表现的影响。
Invest Ophthalmol Vis Sci. 2016 Jul 1;57(9):OCT146-53. doi: 10.1167/iovs.15-18818.
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[Boston-keratoprosthesis : Preliminary experiences in 13 high-risk eyes from the Department of Ophthalmology of the University of Cologne].[波士顿人工角膜:科隆大学眼科13只高危眼中的初步经验]
Ophthalmologe. 2016 Jun;113(6):492-9. doi: 10.1007/s00347-015-0209-1.
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[Subjective asymptomatic corneal opacity after Descemet membrane endothelial keratoplasty].[Descemet膜内皮角膜移植术后主观无症状性角膜混浊]
Ophthalmologe. 2015 Mar;112(3):276-8. doi: 10.1007/s00347-014-3174-1.
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[Standardized Descemet membrane endothelial keratoplasty (DMEK): technique and latest results].[标准化的Descemet膜内皮角膜移植术(DMEK):技术与最新结果]
Ophthalmologe. 2014 Nov;111(11):1041-9. doi: 10.1007/s00347-013-3014-8.
JAMA Ophthalmol. 2013 Jan;131(1):88-9. doi: 10.1001/jamaophthalmol.2013.609.
4
Recurrent interface abscess secondary to Acanthamoeba keratitis treated by deep anterior lamellar keratoplasty.棘阿米巴角膜炎继发复发性界面脓肿,采用深板层角膜移植术治疗。
Int J Ophthalmol. 2012;5(6):774-5. doi: 10.3980/j.issn.2222-3959.2012.06.22. Epub 2012 Dec 18.
5
[Split-cornea transplantation - a novel concept to reduce corneal donor shortage].[角膜分割移植——减少角膜供体短缺的新概念]
Klin Monbl Augenheilkd. 2012 Jun;229(6):608-14. doi: 10.1055/s-0031-1299494. Epub 2012 May 2.
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Descemet membrane endothelial keratoplasty versus descemet stripping automated endothelial keratoplasty.Descemet 膜内皮角膜移植术与 Descemet 撕囊自动化内皮角膜移植术比较。
Am J Ophthalmol. 2012 Jun;153(6):1082-90.e2. doi: 10.1016/j.ajo.2011.12.012. Epub 2012 Mar 6.
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[Immune reactions to posterior lamellar versus penetrating keratoplasty. A retrospective analysis].[对后板层角膜移植术与穿透性角膜移植术的免疫反应。一项回顾性分析]
Ophthalmologe. 2012 Mar;109(3):257-62. doi: 10.1007/s00347-011-2486-7.
8
Efficacy and safety of long-term corticosteroid eye drops after penetrating keratoplasty: a prospective, randomized, clinical trial.穿透性角膜移植术后长期皮质类固醇滴眼液的疗效和安全性:一项前瞻性、随机、临床试验。
Ophthalmology. 2012 Apr;119(4):668-73. doi: 10.1016/j.ophtha.2011.10.016. Epub 2012 Jan 20.
9
Risk of corneal transplant rejection significantly reduced with Descemet's membrane endothelial keratoplasty.穿透性角膜移植术后角膜失代偿的危险因素分析。
Ophthalmology. 2012 Mar;119(3):536-40. doi: 10.1016/j.ophtha.2011.09.019. Epub 2012 Jan 3.
10
Corneal higher-order aberrations after Descemet's membrane endothelial keratoplasty.Descemet 膜内皮角膜移植术后的角膜高阶像差。
Ophthalmology. 2012 Mar;119(3):528-35. doi: 10.1016/j.ophtha.2011.08.034. Epub 2011 Dec 22.