Fadilah S A, Raymond A A, Cheong S K, Faridah A
a Division of Hematology and Stem Cell Transplantation, Department of Medicine , Universiti Kebangsaan Malaysia (UKM) , Jalan Yaacob Latif, Bandar Tun Razak, 56000 Kuala Lumpur , Malaysia.
b Division of Neurology, Department of Medicine , Universiti Kebangsaan Malaysia (UKM) , Jalan Yaacob Latif, Bandar Tun Razak, 56000 Kuala Lumpur , Malaysia.
Hematology. 2001;6(4):267-9. doi: 10.1080/10245332.2001.11752124.
Leukemic infiltration of the optic nerve is rare [1]. [Camera, A., Piccirillo, G., Tranfa, F., Rosa, N., Frigeri, F., Martinelli, V., Rotoloi, B. (1993) "Optic nerve involvement in acute lymphoblastic leukemia", Leuk. Lymph. 11, 153-155]. Radiotherapy should be given urgently to all patients with optic nerve infiltrate to restore their vision [2]. [Rosenthal, A. (1983) "Ocular manifestation of leukemia", Ophthalmology 90, 899-905]. We report a case of a unilateral optic nerve relapse 7 months after diagnosis of acute lymphoblastic leukemia (ALL) in a 17-year-old boy who had been off treatment for 6 weeks. The ocular symptoms was initially diagnosed as primary optic neuritis and treated with corticosteroids resulting in temporary clinical recovery. Radiation therapy for ocular leukemia that was commenced 2 months after the onset of symptoms failed to reverse the visual loss. The lack of a reliable and effective tool to diagnose ocular leukemia at an early stage has resulted in significant treatment delay and poor visual outcome.
白血病对视神经的浸润很少见[1]。[卡迈拉，A.，皮奇里洛，G.，特拉法，F.，罗莎，N.，弗里杰里，F.，马尔蒂内利，V.，罗托洛伊，B.（1993年）“急性淋巴细胞白血病对视神经的累及”，《白血病与淋巴瘤》11，153 - 155页]。对于所有视神经浸润的患者应紧急给予放疗以恢复视力[2]。[罗森塔尔，A.（1983年）“白血病的眼部表现”，《眼科学》90，899 - 905页]。我们报告一例17岁男孩，在急性淋巴细胞白血病（ALL）诊断7个月后出现单侧视神经复发，该男孩已停止治疗6周。眼部症状最初被诊断为原发性视神经炎，并接受了皮质类固醇治疗，临床症状暂时缓解。症状出现2个月后开始的眼部白血病放疗未能逆转视力丧失。缺乏早期诊断眼部白血病的可靠有效工具导致了显著的治疗延迟和不良的视力预后。
