颞下颌关节紊乱病患者椎间盘白细胞介素-1β的免疫组织化学分析
Immunohistochemical analysis of IL-1 beta in the discs of patients with temporomandibular joint dysfunction.
作者信息
Almeida Luis Eduardo, Pierce Sean, Zacharias Joseph, Cullinan William, Noronha Lucia, Olandoski Marcia, Tramontina Vinicius, Loreto Carla, Leonardi Rosalia
机构信息
a Oral Sciences Department, Oral Surgery , School of Dentistry, Marquette University , Milwaukee , WI , USA.
b Biomedical Sciences , College of Health Sciences, Marquette University , Milwaukee , WI , USA.
出版信息
Cranio. 2017 Jul;35(4):233-237. doi: 10.1080/08869634.2016.1207911. Epub 2016 Jul 13.
PURPOSE
Interleukin-1 beta (IL-1β) is a cytokine that participates in the regulation of immune responses and inflammatory reactions. It is hypothesized that IL-1 levels may be elevated in patients suffering from temporomandibular joint dysfunction. The purpose of this study was to determine the association of IL-1β expression with TMD using an immunohistochemical approach to evaluate the joint disc.
MATERIALS AND METHODS
A total of 39 human temporomandibular joint disc samples were collected, with 31 samples in the test group. Nineteen of the test group samples were from discs of patients with anterior disc displacement with reduction, and 12 of the samples were from patients with anterior disc displacement without reduction. Eight control samples were used in the control group. The samples were immunostained and evaluated on both quantity and intensity of staining.
RESULTS
There was a statistically significant difference (p < 0.05) between the control and test groups for both quantity and intensity of staining.
CONCLUSION
IL-1β plays a role in the inflammatory process and degradation of TMJ discs in patients with TMJ dysfunctions.
目的
白细胞介素-1β（IL-1β）是一种参与免疫反应和炎症反应调节的细胞因子。据推测，颞下颌关节紊乱病患者的IL-1水平可能会升高。本研究的目的是使用免疫组织化学方法评估关节盘，以确定IL-1β表达与颞下颌关节紊乱病的关联。
材料与方法
共收集39例人类颞下颌关节盘样本，其中31例样本用于试验组。试验组中的19个样本来自可复性盘前移位患者的关节盘，12个样本来自不可复性盘前移位患者。对照组使用8个对照样本。对样本进行免疫染色，并对染色的数量和强度进行评估。
结果
对照组和试验组在染色数量和强度方面均存在统计学显著差异（p < 0.05）。
结论
IL-1β在颞下颌关节紊乱病患者的颞下颌关节盘炎症过程和退变中起作用。
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