Hussein Ahmed Muzhir, Shaaya Ghazwan, Arora Rohit, Al-Khazaali Ali, Al-Khafaji Khalid, Helu Hanan K
1Department of Internal Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX; 2Captain James A. Lovell Hospital, North Chicago, IL; 3Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL; and 4Northern Illinois University.
Am J Ther. 2016 Nov/Dec;23(6):e1644-e1653. doi: 10.1097/MJT.0000000000000408.
Aortic stiffness (AS) is an important predictor of cardiovascular morbidity in humans. The present review discusses the possible pathophysiological mechanisms of AS and focuses on a survey of different therapeutic modalities for decreasing AS. The influence of several nonpharmacological interventions is described: decrease body weight, diet, aerobic exercise training, music, and continuous positive airway pressure therapy. The effects of different pharmacological drug classes on AS are also discussed: antihypertensive drugs-renin-angiotensin-aldosterone system drugs, beta-blockers, alpha-blockers, diuretics, and calcium channel blockers (CCBs)-advanced glycation end product cross-link breakers, statins, oral anti-diabetics, anti-inflammatory drugs, vitamin D, antioxidant vitamins, and endothelin-1 receptor antagonists. All of these have shown some effect in decreasing AS.
主动脉僵硬度（AS）是人类心血管疾病发病率的重要预测指标。本综述讨论了AS可能的病理生理机制，并着重调查了降低AS的不同治疗方式。描述了几种非药物干预措施的影响：减轻体重、饮食、有氧运动训练、音乐和持续气道正压通气治疗。还讨论了不同类别药物对AS的影响：抗高血压药物——肾素-血管紧张素-醛固酮系统药物、β受体阻滞剂、α受体阻滞剂、利尿剂和钙通道阻滞剂（CCB）——晚期糖基化终产物交联断裂剂、他汀类药物、口服抗糖尿病药物、抗炎药物、维生素D、抗氧化维生素和内皮素-1受体拮抗剂。所有这些都已显示出在降低AS方面有一定作用。
