Caccia M R, Osio M, Galimberti V, Cataldi G, Mangoni A
Neurological Clinic, L. Sacco Hospital, Milan, Italy.
Acta Neurol Scand. 1989 May;79(5):379-83. doi: 10.1111/j.1600-0404.1989.tb03804.x.
Accelerometric tremorgrams were recorded from 25 subjects affected by essential tremor and analysed by a Berg-Fourier frequency analyser before and during venous infusion of the following drugs: propranolol (beta-blocker), clonidine (alpha-presynaptic adrenergic agonist), urapidil (alpha-postsynaptic blocker), trazodone (adrenolytic agent) and placebo. The washout interval between infusions was 3 days. Recordings and data analyses were performed in a double-blind crossover trial. Tremor was classified as: at rest; postural (arms hyperextended); and intention (finger-nose test). Analysis of the results showed that propranolol and clonidine reduced significantly (P = 0.01 and P = 0.009, respectively) the power spectrum of postural tremor, but left at rest and intention tremors unchanged. No significant effects on the tremor power spectrum were observed after placebo, urapidil or trazodone administration. None of the drugs had any effect on tremor frequency.
对25名特发性震颤患者记录加速计震颤图，并在静脉输注以下药物之前和期间通过伯格 - 傅里叶频率分析仪进行分析：普萘洛尔（β受体阻滞剂）、可乐定（α突触前肾上腺素能激动剂）、乌拉地尔（α突触后阻滞剂）、曲唑酮（抗肾上腺素能药）和安慰剂。两次输注之间的洗脱期为3天。记录和数据分析在双盲交叉试验中进行。震颤分为：静止性；姿势性（手臂过度伸展）；意向性（指鼻试验）。结果分析表明，普萘洛尔和可乐定显著降低（分别为P = 0.01和P = 0.009）姿势性震颤的功率谱，但静止性和意向性震颤未改变。给予安慰剂、乌拉地尔或曲唑酮后，未观察到对震颤功率谱有显著影响。没有一种药物对震颤频率有任何影响。
