Calzetti S, Sasso E, Negrotti A, Baratti M, Fava R
Institute of Neurology, University of Parma, Italy.
Clin Neuropharmacol. 1992 Dec;15(6):470-6. doi: 10.1097/00002826-199212000-00004.
The effect of the beta-adrenoceptor antagonist propranolol has been investigated in nine patients suffering from isolated (six patients) or prominent (three patients) essential tremor of the head. In a double-blind, placebo-controlled study the tremorolytic efficacy of propranolol has been assessed by a quantitative accelerometric method after a single oral dose (120 mg) and following 2 weeks of sustained treatment with two different dosage regimens of the drug (120 and 240 mg daily). As compared with placebo, a significant reduction in tremor magnitude was found following a single oral dose but not on sustained administration of the beta-blocker at either dosage. The results suggest that the efficacy of sustained propranolol on isolated or prominent essential head tremor is less predictable and satisfactory than expected on the basis of the single-dose response, as compared with hand tremor.
对9例患有孤立性（6例）或显著（3例）头部特发性震颤的患者，研究了β肾上腺素能受体拮抗剂普萘洛尔的效果。在一项双盲、安慰剂对照研究中，通过定量加速度测量法评估了普萘洛尔单次口服剂量（120毫克）后以及使用两种不同剂量方案（每日120毫克和240毫克）持续治疗2周后的震颤缓解疗效。与安慰剂相比，单次口服剂量后震颤幅度显著降低，但两种剂量的β受体阻滞剂持续给药时均未出现这种情况。结果表明，与手部震颤相比，普萘洛尔持续治疗对孤立性或显著的头部特发性震颤的疗效比基于单剂量反应预期的更难预测且效果欠佳。
