Liu Yue-Fang, Deng Wen-Bo, Li Shu-Yun, Yao Mei-Nan, Liu Jie, Dou Hai-Tin, Zhao Meng-Long, Yang Zeng-Ming, Liang Xiao-Huan
College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Department of Biology, Shantou University, China.
FEBS Lett. 2016 Aug;590(16):2594-602. doi: 10.1002/1873-3468.12304. Epub 2016 Jul 29.
Lipocalin-2 (Lcn2) is a small glycoprotein involved in a number of biological processes such as inflammation and antibacterial response. In our study, Lcn2 is expressed in the subluminal stromal cells at implantation site on day 5 of pregnancy. The expression of Lcn2 in stromal cells is under the control of progesterone through Akt-c-Myc signaling pathway. Data from Lcn2 knockdown and recombinant protein treatments indicate that Lcn2 promotes mPGES-1 expression in stromal cells. The expression of Lcn2 and mPGES-1 is strongly stimulated by lipopolysaccharide (LPS), indicating that Lcn2 mediates LPS-induced inflammation. These findings shed light on the role of Lcn2 during decidualization.
脂质运载蛋白-2（Lcn2）是一种小糖蛋白，参与多种生物学过程，如炎症和抗菌反应。在我们的研究中，Lcn2在妊娠第5天植入部位的腔下基质细胞中表达。基质细胞中Lcn2的表达受孕酮通过Akt-c-Myc信号通路的调控。Lcn2基因敲低和重组蛋白处理的数据表明，Lcn2促进基质细胞中mPGES-1的表达。脂多糖（LPS）强烈刺激Lcn2和mPGES-1的表达，表明Lcn2介导LPS诱导的炎症。这些发现揭示了Lcn2在蜕膜化过程中的作用。
