• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

感染伊氏锥虫的大鼠心脏中的氧化应激

Oxidative Stress in the Heart of Rats Infected with Trypanosoma evansi.

作者信息

Baldissera Matheus D, Souza Carine de F, Bertoncheli Cláudia M, Silveira Karine L da, Grando Thirssa H, Porto Bianca C Z, Leal Daniela B R, Silva Aleksandro S Da, Mendes Ricardo E, Stefani Lenita M, Monteiro Silvia G

机构信息

Department of Microbiology and Parasitology, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil.

Department of Pharmacology and Physiology, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil.

出版信息

Korean J Parasitol. 2016 Jun;54(3):247-52. doi: 10.3347/kjp.2016.54.3.247. Epub 2016 Jun 30.

DOI:10.3347/kjp.2016.54.3.247
PMID:27417077
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4977782/
Abstract

This study was conducted to investigate the occurrence of oxidative stress in the heart tissue of rats infected with Trypanosoma evansi. Rats were divided into 2 groups (A and B) with 12 animals each, and further subdivided into 4 subgroups (A1 and A2, 6 animals/each; and B1 and B2, 6 animals/each). Animals in the groups B1 and B2 were subcutaneously inoculated with T. evansi. Thiobarbituric acid reactive substances (TBARS), superoxide dismutase activity (SOD), glutathione S-transferase activity (GST), reduced glutathione activity (GSH), and non-protein thiols (NPSH) in the heart tissue were evaluated. At day 5 and 15 post-infection (PI), an increase in the TBARS levels and a decrease in the SOD activity (P<0.05) were observed. GSH and GST activities were decreased in infected animals at day 15 PI (P<0.05). Considering the proper functioning of the heart, it is possible that the changes in the activity of these enzymes involved in the oxidative stress may be related, at least in part, in the pathophysiology of rats infected with T. evansi.

摘要

本研究旨在调查感染伊氏锥虫的大鼠心脏组织中氧化应激的发生情况。将大鼠分为2组（A组和B组），每组12只动物，并进一步细分为4个亚组（A1和A2，每组6只动物；B1和B2，每组6只动物）。B1组和B2组的动物皮下接种伊氏锥虫。评估心脏组织中的硫代巴比妥酸反应性物质（TBARS）、超氧化物歧化酶活性（SOD）、谷胱甘肽S-转移酶活性（GST）、还原型谷胱甘肽活性（GSH）和非蛋白巯基（NPSH）。在感染后第5天和第15天，观察到TBARS水平升高和SOD活性降低（P<0.05）。在感染后第15天，感染动物的GSH和GST活性降低（P<0.05）。考虑到心脏的正常功能，参与氧化应激的这些酶活性的变化可能至少部分与感染伊氏锥虫的大鼠的病理生理学有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9efe/4977782/b1383ea77b73/kjp-54-3-247f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9efe/4977782/484da4bbe44e/kjp-54-3-247f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9efe/4977782/626e4ed54217/kjp-54-3-247f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9efe/4977782/55abe569c727/kjp-54-3-247f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9efe/4977782/b1383ea77b73/kjp-54-3-247f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9efe/4977782/484da4bbe44e/kjp-54-3-247f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9efe/4977782/626e4ed54217/kjp-54-3-247f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9efe/4977782/55abe569c727/kjp-54-3-247f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9efe/4977782/b1383ea77b73/kjp-54-3-247f4.jpg

相似文献

1
Oxidative Stress in the Heart of Rats Infected with Trypanosoma evansi.感染伊氏锥虫的大鼠心脏中的氧化应激
Korean J Parasitol. 2016 Jun;54(3):247-52. doi: 10.3347/kjp.2016.54.3.247. Epub 2016 Jun 30.
2
Trypanosoma evansi: Ca(2+) ATPase activity and lipid peroxidation in skeletal muscle from rats experimentally infected.伊氏锥虫：实验感染大鼠骨骼肌中的 Ca(2+)ATP 酶活性和脂质过氧化作用。
Exp Parasitol. 2011 Aug;128(4):377-81. doi: 10.1016/j.exppara.2011.05.004. Epub 2011 May 15.
3
Achyrocline satureioides essential oil loaded in nanocapsules ameliorate the antioxidant/oxidant status in heart of rats infected with Trypanosoma evansi.负载于纳米胶囊中的牛膝草精油改善了感染伊氏锥虫的大鼠心脏中的抗氧化/氧化状态。
Microb Pathog. 2017 Apr;105:30-36. doi: 10.1016/j.micpath.2017.02.005. Epub 2017 Feb 6.
4
Nerolidol-loaded nanospheres prevent behavioral impairment via ameliorating Na, K-ATPase and AChE activities as well as reducing oxidative stress in the brain of Trypanosoma evansi-infected mice.负载橙花叔醇的纳米球通过改善钠钾ATP酶和乙酰胆碱酯酶活性以及降低伊氏锥虫感染小鼠大脑中的氧化应激来预防行为障碍。
Naunyn Schmiedebergs Arch Pharmacol. 2017 Feb;390(2):139-148. doi: 10.1007/s00210-016-1313-8. Epub 2016 Nov 2.
5
Relationship between DNA damage in liver, heart, spleen and total blood cells and disease pathogenesis of infected rats by Trypanosoma evansi.
Exp Parasitol. 2016 Feb;161:12-9. doi: 10.1016/j.exppara.2015.12.008. Epub 2015 Dec 17.
6
Nerolidol-loaded nanospheres prevent hepatic oxidative stress of mice infected by Trypanosoma evansi.负载橙花叔醇的纳米球可预防感染伊氏锥虫的小鼠肝脏氧化应激。
Parasitology. 2017 Feb;144(2):148-157. doi: 10.1017/S0031182016001803. Epub 2016 Oct 17.
7
Involvement of oxidative stress, cholinergic and adenosinergic systems on renal damage caused by Trypanosoma evansi infection: Relationship with lipid peroxidation.氧化应激、胆碱能和腺苷能系统在伊氏锥虫感染所致肾损伤中的作用：与脂质过氧化的关系。
Microb Pathog. 2016 Oct;99:191-195. doi: 10.1016/j.micpath.2016.08.028. Epub 2016 Aug 24.
8
Delta-aminolevulinate dehydratase activity in red blood cells of rats infected with Trypanosoma evansi.感染伊氏锥虫的大鼠红细胞中δ-氨基乙酰丙酸脱水酶活性。
Parasitology. 2011 Sep;138(10):1272-7. doi: 10.1017/S0031182011000989.
9
Acetylcholinesterase activity and lipid peroxidation in the brain and spinal cord of rats infected with Trypanosoma evansi.感染伊氏锥虫的大鼠脑和脊髓中的乙酰胆碱酯酶活性和脂质过氧化作用。
Vet Parasitol. 2011 Feb 10;175(3-4):237-44. doi: 10.1016/j.vetpar.2010.10.021. Epub 2010 Oct 20.
10
Age-related changes of antioxidant enzyme activities, glutathione status and lipid peroxidation in rat erythrocytes after heat stress.热应激后大鼠红细胞中抗氧化酶活性、谷胱甘肽状态及脂质过氧化的年龄相关性变化
Life Sci. 2004 Aug 13;75(13):1551-65. doi: 10.1016/j.lfs.2004.03.020.

引用本文的文献

1
Novel insights into antioxidant status, gene expression, and immunohistochemistry in an animal model infected with camel-derived Trypanosoma evansi and Theileria annulata.骆驼源伊氏锥虫和环形泰勒虫感染动物模型中抗氧化状态、基因表达和免疫组织化学的新见解。
Parasit Vectors. 2024 Nov 18;17(1):474. doi: 10.1186/s13071-024-06564-3.
2
Molecular and phylogenetic analysis of a type K1 strain isolate from Nigerian cattle: An evaluation of the therapeutic effects of compounds from on the histopathology of infected wister rats.从尼日利亚牛分离出的一株K1型菌株的分子和系统发育分析：对来自……的化合物对感染的Wistar大鼠组织病理学治疗效果的评估 。 （注：原文中“from”后面似乎缺失了具体信息）
Biochem Biophys Rep. 2023 Jan 10;33:101424. doi: 10.1016/j.bbrep.2023.101424. eCollection 2023 Mar.

本文引用的文献

1
Enzymatic activities linked to cardiac energy metabolism of Trypanosoma evansi-infected rats and their possible functional correlations to disease pathogenesis.与伊氏锥虫感染大鼠心脏能量代谢相关的酶活性及其与疾病发病机制的可能功能关联。
Parasitology. 2015 Aug;142(9):1163-70. doi: 10.1017/S0031182015000220. Epub 2015 Mar 11.
2
Cardiac and oxidative stress biomarkers in Trypanosoma evansi infected camels: diagnostic and prognostic prominence.伊氏锥虫感染骆驼的心脏和氧化应激生物标志物：诊断和预后意义
Parasitology. 2015 May;142(6):767-72. doi: 10.1017/S0031182014001899. Epub 2015 Jan 12.
3
Treatment with essential oil of Achyrocline satureioides in rats infected with Trypanosoma evansi: relationship between protective effect and tissue damage.
用牛膝草精油治疗感染伊氏锥虫的大鼠：保护作用与组织损伤之间的关系。
Pathol Res Pract. 2014 Dec;210(12):1068-74. doi: 10.1016/j.prp.2014.06.008. Epub 2014 Jun 24.
4
Glutathione and iron at the crossroad of redox metabolism in rats infected by Trypanosoma evansi.感染伊氏锥虫的大鼠氧化还原代谢交汇点的谷胱甘肽和铁。
Parasitol Res. 2013 Jun;112(6):2361-6. doi: 10.1007/s00436-013-3400-9. Epub 2013 Mar 26.
5
Oxidative stress and myocardial injury in the diabetic heart.氧化应激与糖尿病心脏中的心肌损伤。
J Pathol. 2013 Jan;229(2):232-41. doi: 10.1002/path.4113.
6
Nitric oxide level, protein oxidation and antioxidant enzymes in rats infected by Trypanosoma evansi.感染伊氏锥虫的大鼠的一氧化氮水平、蛋白质氧化和抗氧化酶。
Exp Parasitol. 2012 Oct;132(2):166-70. doi: 10.1016/j.exppara.2012.06.010. Epub 2012 Jul 4.
7
Oxidative Stress and Inflammation in Heart Disease: Do Antioxidants Have a Role in Treatment and/or Prevention?心脏病中的氧化应激与炎症：抗氧化剂在治疗和/或预防中起作用吗？
Int J Inflam. 2011;2011:514623. doi: 10.4061/2011/514623. Epub 2011 Aug 11.
8
Disturbance of oxidant/antioxidant equilibrium in horses naturally infected with Trypanosoma evansi.天然感染伊氏锥虫的马体内氧化剂/抗氧化剂平衡的紊乱。
Vet Parasitol. 2011 Aug 25;180(3-4):349-53. doi: 10.1016/j.vetpar.2011.03.029. Epub 2011 Mar 31.
9
Reactive oxygen species, cellular redox systems, and apoptosis.活性氧、细胞氧化还原系统与细胞凋亡。
Free Radic Biol Med. 2010 Mar 15;48(6):749-62. doi: 10.1016/j.freeradbiomed.2009.12.022. Epub 2010 Jan 4.
10
Lipid peroxidation associated with anemia in rats experimentally infected with Trypanosoma evansi.实验感染伊氏锥虫后大鼠贫血与脂质过氧化的关系。
Vet Parasitol. 2009 Oct 28;165(1-2):41-6. doi: 10.1016/j.vetpar.2009.06.032. Epub 2009 Jul 2.