Chen Kuan-Hua, Okerstrom Katrina L, Kingyon Jonathan R, Anderson Steven W, Cavanagh James F, Narayanan Nandakumar S
University of Iowa.
University of New Mexico.
J Cogn Neurosci. 2016 Dec;28(12):1923-1932. doi: 10.1162/jocn_a_01012. Epub 2016 Jul 15.
The ability to adapt to aversive stimuli is critical for mental health. Here, we investigate the relationship between habituation to startling stimuli and startle-related activity in medial frontal cortex as measured by EEG in both healthy control participants and patients with Parkinson disease (PD). We report three findings. First, patients with PD exhibited normal initial startle responses but reduced startle habituation relative to demographically matched controls. Second, control participants had midfrontal EEG theta activity in response to startling stimuli, and this activity was attenuated in patients with PD. Finally, startle-related midfrontal theta activity was correlated with the rate of startle habituation. These data indicate that impaired startle habituation in PD is a result of attenuated midfrontal cognitive control signals. Our findings could provide insight into the frontal regulation of startle habituation.
适应厌恶刺激的能力对心理健康至关重要。在此，我们研究了健康对照参与者和帕金森病（PD）患者中，通过脑电图（EEG）测量的对惊吓刺激的习惯化与内侧前额叶皮质中与惊吓相关的活动之间的关系。我们报告了三项发现。首先，相对于人口统计学匹配的对照组，PD患者表现出正常的初始惊吓反应，但惊吓习惯化降低。其次，对照参与者在受到惊吓刺激时会出现额中 EEG θ 活动，而PD患者的这种活动减弱。最后，与惊吓相关的额中 θ 活动与惊吓习惯化速率相关。这些数据表明，PD患者惊吓习惯化受损是额中认知控制信号减弱的结果。我们的发现可能为惊吓习惯化的额叶调节提供见解。
