类风湿关节炎中细胞因子水平及半胱天冬酶基因的表达
The level of cytokines and expression of caspase genes in rheumatoid arthritis.
作者信息
Malysheva I E, Topchieva L V, Barysheva O Y, Kurbatova I V, Vasykova O A, Vezikova N N, Marusenko I M, Nemova N N
机构信息
Institute of Biology, Karelian Research Center, Russian Academy of Sciences, ul. Pushkinskaya 11, Petrozavodsk, 185910, Karelia, Russia.
Petrozavodsk State University, pr. Lenina 33, Petrozavodsk, Karelia, 185910, Russia.
出版信息
Dokl Biochem Biophys. 2016 May;468(1):226-8. doi: 10.1134/S1607672916030194. Epub 2016 Jul 15.
The level of TNFα and IL6 in the blood plasma of patients with rheumatoid arthritis (RA) who received antiinflammatory therapy with methotrexate (MT) was significantly lower than in the patients without MT treatment. The level of caspase 6 and 9 gene transcripts in peripheral blood lymphocytes in patients with rheumatoid arthritic diagnosed for the first time and in patients with MT treatment were not significantly different. At the same time, the level of caspase 3 mRNA expression was significantly higher in the cells of the RA patients with MT therapy compared to the patients without MT therapy.
接受甲氨蝶呤（MT）抗炎治疗的类风湿关节炎（RA）患者血浆中TNFα和IL6水平显著低于未接受MT治疗的患者。首次诊断为类风湿关节炎的患者及接受MT治疗的患者外周血淋巴细胞中caspase 6和9基因转录水平无显著差异。同时，与未接受MT治疗的患者相比，接受MT治疗的RA患者细胞中caspase 3 mRNA表达水平显著更高。
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