Wang Jingyun, Neely Daniel E, Galli Jay, Schliesser Joshua, Graves April, Damarjian Tina G, Kovarik Jessica, Bowsher James, Smith Heather A, Donaldson Dana, Haider Kathryn M, Roberts Gavin J, Sprunger Derek T, Plager David A
Salus University Pennsylvania College of Optometry, Elkins Park, Pennsylvania; Eugene and Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, Indianapolis.
Eugene and Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, Indianapolis.
J AAPOS. 2016 Aug;20(4):326-31. doi: 10.1016/j.jaapos.2016.05.014. Epub 2016 Jul 12.
To compare the effectiveness of intermittent occlusion therapy (IO therapy) using liquid crystal glasses and continuous occlusion therapy using traditional adhesive patches for treating amblyopia.
Children 3-8 years of age with previously untreated, moderate, unilateral amblyopia (visual acuity of 20/40 to 20/100 in the amblyopic eye) were enrolled in this randomized controlled trial. Amblyopia was associated with strabismus, anisometropia, or both. All subjects had worn any optimal refractive correction for at least 12 weeks without improvement. Subjects were randomized into two treatment groups: a 4-hour IO therapy group with liquid crystal glasses (Amblyz), set at 30-second opaque/transparent intervals (occluded 50% of wear time), and a 2-hour continuous patching group (occluded 100% of wear time). For each patient, visual acuity was measured using ATS-HOTV before and after 12 weeks of treatment.
Data from 34 patients were available for analysis. Amblyopic eye visual acuity improvement from baseline was 0.15 ± 0.12 logMAR (95% CI, 0.09-0.15) in the IO therapy group (n = 19) and 0.15 ± 0.11 logMAR (95% CI, 0.1-0.15) in the patching group (n = 15). In both groups improvement was significant, but the difference between groups was not (P = 0.73). No adverse effects were reported.
In this pilot study, IO therapy with liquid crystal glasses is not inferior to adhesive patching and is a promising alternative treatment for children 3-8 years of age with moderate amblyopia.
比较使用液晶眼镜的间歇性遮盖疗法（IO疗法）与使用传统粘贴眼罩的持续性遮盖疗法治疗弱视的效果。
本随机对照试验纳入了3至8岁、先前未经治疗的中度单侧弱视（弱视眼视力为20/40至20/100）儿童。弱视与斜视、屈光参差或两者均有关。所有受试者均已佩戴最佳屈光矫正至少12周但无改善。受试者被随机分为两个治疗组：一个使用液晶眼镜（Amblyz）的4小时IO疗法组，设置为30秒不透明/透明间隔（遮盖佩戴时间的50%），以及一个2小时持续性眼罩组（遮盖佩戴时间的100%）。对每位患者在治疗12周前后使用ATS-HOTV测量视力。
34例患者的数据可供分析。IO疗法组（n = 19）弱视眼视力从基线的改善为0.15±0.12 logMAR（95%CI，0.09 - 0.15），眼罩组（n = 15）为0.15±0.11 logMAR（95%CI，0.1 - 0.15）。两组的改善均显著，但组间差异不显著（P = 0.73）。未报告不良反应。
在这项初步研究中，使用液晶眼镜的IO疗法不劣于粘贴眼罩，是3至8岁中度弱视儿童一种有前景的替代治疗方法。
