Pediatric Vision Laboratory, Retina Foundation of the Southwest, 9600 North Central Expressway #200, Dallas, TX, 75225, USA; Department of Ophthalmology, University of Texas Southwestern Medical Center, 5303 Harry Hines Boulevard, Dallas, TX, 75390, USA.
Department of Ophthalmology, University of Texas Southwestern Medical Center, 5303 Harry Hines Boulevard, Dallas, TX, 75390, USA; Vision and Neurodevelopment Laboratory, Retina Foundation of the Southwest, 9600 North Central Expressway #200, Dallas, TX, 75225, USA.
Prog Retin Eye Res. 2023 Mar;93:101168. doi: 10.1016/j.preteyeres.2023.101168. Epub 2023 Feb 1.
Amblyopia is a disorder of neurodevelopment that occurs when there is discordant binocular visual experience during the first years of life. While treatments are effective in improving visual acuity, there are significant individual differences in response to treatment that cannot be attributed solely to difference in adherence. In this considerable variability in response to treatment, we argue that treatment outcomes might be optimized by utilizing deep phenotyping of amblyopic deficits to guide alternative treatment choices. In addition, an understanding of the broader knock-on effects of amblyopia on developing visually-guided skills, self-perception, and quality of life will facilitate a whole person healthcare approach to amblyopia.
弱视是一种神经发育障碍，当生命的最初几年存在双眼视觉经验不一致时就会发生。虽然治疗可以有效提高视力，但对治疗的反应存在显著的个体差异，不能仅仅归因于治疗的依从性差异。在这种对治疗的反应存在很大差异的情况下，我们认为通过利用弱视缺陷的深度表型来指导替代治疗选择，可能会优化治疗效果。此外，了解弱视对正在发育的视觉引导技能、自我认知和生活质量的更广泛连锁影响，将有助于弱视的整体医疗保健方法。
