Ozkayar N, Akyel S, Dede F, Akyel F, Turgut D, Bulut M, Odabaş A R
Nephrology Department, Ankara Numune Education and Research Hospital, Ankara, Turkey.
Cardiology Department, Ankara Numune Education and Research Hospital, Ankara, Turkey.
Hippokratia. 2015 Apr-Jun;19(2):109-13.
BACKGROUND/AIM: Abnormal heart rate recovery after an exercise stress test is a strong predictor of cardiovascular death in healthy subjects and various patient groups. The aim of the present study was to investigate heart rate recovery (HRR), a cardiovascular risk factor, in patients with primary nephrotic syndrome (NS).
Forty patients with primary NS (mean age 39.6 ± 9.3 years) and 42 healthy subjects (mean age 36.0 ± 7.9) were included in the study. HRR was calculated by subtracting the heart rates in the first, second, and third minutes of the recovery period from the maximum heart rate, reached during the exercise stress test.
The HRR in the first minute was significantly slower in the NS group compared with the control group (25.5 ± 10.1 and 32.4 ± 11.1, respectively; p =0.004). The HRR in the second and third minutes was also slower in the NS group, but the difference was not statistically significant. When a comparative analysis of HRR and the etiology of NS was carried out, no difference was found at any time point.
Impaired first minute HRR was identified in patients with NS. This suggests that primary NS patients should be monitored due to the potential increased risk of cardiovascular disease. Hippokratia 2015; 19 (2):109-113.
背景/目的：运动应激试验后心率恢复异常是健康受试者和各类患者群体心血管死亡的有力预测指标。本研究旨在调查原发性肾病综合征（NS）患者的心率恢复情况（HRR），这是一种心血管危险因素。
本研究纳入了40例原发性NS患者（平均年龄39.6±9.3岁）和42名健康受试者（平均年龄36.0±7.9岁）。HRR通过用运动应激试验期间达到的最大心率减去恢复期第1、2、3分钟的心率来计算。
NS组第1分钟的HRR明显慢于对照组（分别为25.5±10.1和32.4±11.1；p=0.004）。NS组第2分钟和第3分钟的HRR也较慢，但差异无统计学意义。对HRR与NS病因进行比较分析时，在任何时间点均未发现差异。
NS患者存在第1分钟HRR受损的情况。这表明原发性NS患者因心血管疾病潜在风险增加而应接受监测。《希波克拉底》2015年；19（2）：109-113。
