1Division of Rheumatology, School of Medicine, University of São Paulo, Brazil.
Lupus. 2011 Jun;20(7):717-20. doi: 10.1177/0961203310397081.
Abnormal heart-rate (HR) response during or after a graded exercise test has been recognized as a strong and an independent predictor of all-cause mortality in healthy and diseased subjects. The purpose of the present study was to evaluate the HR response during exercise in women with systemic lupus erythematosus (SLE). In this case-control study, 22 women with SLE (age 29.5 ± 1.1 years) were compared with 20 gender-, BMI-, and age-matched healthy subjects (age 26.5 ± 1.4 years). A treadmill cardiorespiratory test was performed and HR response during exercise was evaluated by the chronotropic reserve (CR). HR recovery (ΔHRR) was defined as the difference between HR at peak exercise and at both first (ΔHRR1) and second (ΔHRR2) minutes after exercising. SLE patients presented lower peak VO(2) when compared with healthy subjects (27.6 ± 0.9 vs. 36.7 ± 1.1 ml/kg/min, p = 0.001, respectively). Additionally, SLE patients demonstrated lower CR (71.8 ± 2.4 vs. 98.2 ± 2.6%, p = 0.001), ΔHRR1 (22.1 ± 2.5 vs. 32.4 ± 2.2%, p = 0.004) and ΔHRR2 (39.1 ± 2.9 vs. 50.8 ± 2.5%, p = 0.001) than their healthy peers. In conclusion, SLE patients presented abnormal HR response to exercise, characterized by chronotropic incompetence and delayed ΔHRR.
在分级运动试验期间或之后出现异常心率（HR）反应已被认为是健康和患病受试者全因死亡率的一个强有力且独立的预测因素。本研究的目的是评估系统性红斑狼疮（SLE）女性在运动过程中的 HR 反应。在这项病例对照研究中，将 22 名 SLE 女性（年龄 29.5±1.1 岁）与 20 名性别、BMI 和年龄匹配的健康受试者（年龄 26.5±1.4 岁）进行比较。进行了跑步机心肺运动测试，并通过变时储备（CR）评估运动过程中的 HR 反应。HR 恢复（ΔHRR）定义为运动峰值时的 HR 与运动后第一分钟（ΔHRR1）和第二分钟（ΔHRR2）时的 HR 之间的差异。与健康受试者相比，SLE 患者的峰值 VO2 较低（分别为 27.6±0.9 与 36.7±1.1 ml/kg/min，p=0.001）。此外，SLE 患者的 CR（71.8±2.4 与 98.2±2.6%，p=0.001）、ΔHRR1（22.1±2.5 与 32.4±2.2%，p=0.004）和 ΔHRR2（39.1±2.9 与 50.8±2.5%，p=0.001）也低于其健康对照组。总之，SLE 患者在运动时表现出异常的 HR 反应，表现为变时功能不全和 ΔHRR 延迟。
