Kiguchi H, Kasahara K, Mochizuki M, Yasuda Y, Ishibashi T, Konishi F, Kanazawa K, Saitoh K, Waza K, Kawamura H
Department of Surgery, Jichi Medical School, Tochigi, Japan.
Am J Gastroenterol. 1989 Jul;84(7):808-10.
Panperitonitis developed in a 57-yr-old Japanese man during the course of Weber-Christian disease (WCD). Emergent operation disclosed three perforations of the ascending colon and two of the distal ileum. Histological study of the surgical specimen showed that all perforations were located at the centers of acute subserosal panniculitic foci. No vasculitis was discerned. In the previously reported three cases of WCD with intestinal perforation, perforation was solitary and seen in the small intestine. The cause of perforation was considered to be vasculitis in two cases. In the remaining one, panniculitis around the perforation was in chronic granulomatous stage. This was the first case of WCD in which acute subserosal panniculitis caused multiple ileocolonic perforations.
一名57岁的日本男性在患韦格纳-克里斯蒂安病（WCD）期间发生了泛发性腹膜炎。急诊手术发现升结肠有三处穿孔，回肠末端有两处穿孔。手术标本的组织学研究表明，所有穿孔均位于急性浆膜下脂膜炎病灶的中心。未发现血管炎。在先前报道的3例WCD合并肠穿孔病例中，穿孔为单发，见于小肠。2例穿孔原因被认为是血管炎。在其余1例中，穿孔周围的脂膜炎处于慢性肉芽肿期。这是首例由急性浆膜下脂膜炎导致多发回结肠穿孔的WCD病例。
