Mandal Rupali, Mondal Krishnendu
Department of Pathology, North Bengal Medical College and Hospital, India.
J Tradit Complement Med. 2015 Apr 3;6(3):224-9. doi: 10.1016/j.jtcme.2015.02.003. eCollection 2016 Jul.
In modern health services, blood transfusion is an essentially life-saving manoeuvre. With this situation healthy donor compilation is the cornerstone of transfusion medicine. Henceforth, a provision for strict criterion in recruitment and deferral of blood donors, particularly emphasizing transfusion transmissible infections (TTI), may improve safe transfusion practice.
The present study was executed to assess the prevalence of TTIs within blood donors at a sub-Himalayan rural tertiary care institution in Darjeeling, India; which can ultimately aid in determination of the population subset to be targeted for enhancing donor pool.
The present study was a three-year (2010-2012) retrospective study. Data was accumulated and analysed from blood bank records, pertaining to all donors who were screened for various TTIs using respective immunological methods. Then the tabulated seropositive donors were correlated with relevant epidemiological profiles.
Total 28,364 blood donors were examined, comprising of 25,517 (89.96%) males and 20,985 (73.98%) voluntary donors. Cumulative seroprevalence of HIV, HBV, HCV and syphilis were 0.42%, 1.24%, 0.62% and 0.65% respectively; with solitary malaria-infected donor. The overall seroreactivity in present study significantly diminished through successive years.
Deployment of implicit inclusion-exclusion criteria is high on demand for reducing the prevalence of TTIs, to increase the donor subpopulation strength and ultimately to institute a safe transfusion protocol.
在现代医疗服务中，输血是一项至关重要的挽救生命的操作。在这种情况下，健康献血者招募是输血医学的基石。因此，制定严格的献血者招募和延期标准，特别是强调输血传播感染（TTI），可能会改善安全输血实践。
本研究旨在评估印度大吉岭喜马拉雅山脚下一家农村三级医疗机构献血者中TTI的流行情况；这最终有助于确定为扩大献血者库而应针对的人群子集。
本研究是一项为期三年（2010 - 2012年）的回顾性研究。从血库记录中收集并分析数据，这些记录涉及所有使用各自免疫方法筛查各种TTI的献血者。然后将制成表格的血清学阳性献血者与相关的流行病学资料进行关联。
共检查了28364名献血者，其中男性25517名（89.96%），自愿献血者20985名（73.98%）。HIV、HBV、HCV和梅毒的累积血清阳性率分别为0.42%、1.24%、0.62%和0.65%；有一名单独的疟疾感染献血者。本研究中的总体血清反应性在连续几年中显著降低。
迫切需要采用隐含的纳入 - 排除标准来降低TTI的流行率，增加献血者亚群数量，并最终建立安全的输血方案。
