Kojom Foko Loick P, Sharma Shweta, Sharma Amit
Molecular Medicine Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, 110067, India.
Center for Expertise and Research in Applied Biology (CEREBA), Douala, 3787, Cameroon.
Lancet Reg Health Southeast Asia. 2025 Jul 22;40:100641. doi: 10.1016/j.lansea.2025.100641. eCollection 2025 Sep.
Blood transfusion is a globally life-saving intervention, but blood-borne pathogens can threaten its effectiveness. While blood bags are systematically screened for viral and bacterial pathogens, parasite infections are generally overlooked. In this review, we analysed the current literature on transfusion-transmitted malaria (TTM) in India over the past five decades. This analysis is based on 122 studies involving more than 6.5 million individuals. The prevalence of parasitaemia in donors ranged from ∼0% to 0.87% by light microscopy and ∼0% to 2.3% by rapid diagnostic tests. The proportion of post-transfusion malaria (PTM) cases ranged from 0.8% to 6.8% across the studies. The risk of PTM is both time- and diagnosis method-dependent and relatively high in some regions of India. The clinical impacts of PTM range from mild to severe and even fatal outcomes. It is also crucial to address TTM given the often-neglected , in addition to the prevalence of and . The spread of drug-resistant and/or gene-deleted parasites is another threat in PTM. Blood screening could be achieved through point-of-care nucleic acid amplification techniques to guarantee safer transfusion. If neglected, TTM can become an obstacle to malaria elimination in the coming years.
输血是一项全球范围内挽救生命的干预措施，但血源性病原体可能会威胁到其有效性。虽然血袋会系统地筛查病毒和细菌病原体，但寄生虫感染通常被忽视。在本综述中，我们分析了过去五十年来印度关于输血传播疟疾（TTM）的现有文献。该分析基于122项涉及650多万人的研究。通过光学显微镜检查，献血者中疟原虫血症的患病率在约0%至0.87%之间，通过快速诊断检测则在约0%至2.3%之间。在各项研究中，输血后疟疾（PTM）病例的比例在0.8%至6.8%之间。PTM的风险既取决于时间，也取决于诊断方法，在印度的一些地区相对较高。PTM的临床影响范围从轻度到重度，甚至会导致致命后果。鉴于[此处原文缺失部分内容]常常被忽视，以及[此处原文缺失部分内容]的流行情况，解决TTM问题也至关重要。耐药和/或基因缺失疟原虫的传播是PTM中的另一个威胁。可通过即时护理核酸扩增技术进行血液筛查，以确保输血更安全。如果被忽视，TTM可能会在未来几年成为疟疾消除的障碍。
